摘要
目的探讨急性心肌梗死(AMI)患者血浆致动脉硬化指数(AIP)、血尿酸(SUA)水平的变化及临床意义。方法选取90例确诊为AMI并行急诊冠状动脉造影明确单支或多支血管狭窄≥50%的患者为AMI组,90例同期拟诊为冠心病并行择期冠状动脉造影明确血管狭窄均<50%的患者为对照组。根据AMI组受累血管支数又将其分为3个亚组:单支血管病变组、双支血管病变组及多支血管病变组。所有患者均抽取空腹12 h静脉血,测量血脂、SUA及其他生化指标并计算AIP值,比较两组及亚组之间的差异。结果 (1)与对照组相比,AMI组三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、AIP和SUA水平较高及HDL-C水平较低(P<0.05);(2)AMI组内比较发现,随着冠状动脉病变程度加重,AIP、SUA均呈升高趋势,且均与冠状动脉病变程度呈正相关(r=0.356,r=0.300,P<0.05);多支血管病变组与对照组比较,AIP明显升高(P<0.05),其余各组间两两比较均无统计学差异(P>0.05);AMI各亚组与对照组相比SUA均明显升高(P<0.05),但各亚组两两比较均无统计学差异(P>0.05);(3)Logistic回归分析提示SUA水平升高是AMI的相关危险因素(P<0.05)。结论 AIP、SUA在AMI患者中具有较高水平,且均与冠状动脉病变程度正相关。
Objective To study the changes in atherogenic indexes of plasma （ALP） and serum uric acid （SUA） in patients with acute myocardial infarction （AMI） and their clinical significance. Methods Patients were recruited and assigned into two groups. AMI group included 90 patients diagnosed as AMI with stenosis （stenoses） ≥ 50% and control group included another 90 ones diag- nosed as AMI with stenosis （stenoses） 〈 50%. The AMI group was then divided into three sub-groups according to the number of the stenosed coronary arteries. Venous blood was collected after 12h fasting. Blood lipids, SUA and API value were analyzed in all the patients and compared between groups and sub-groups. Results （ 1 ） Compared with the control group, the AMI group had higher levels of triglyeeride （TG） , total cholesterol （TC） , low-density lipoprotein cholesterol （LDL-C） , AlP, SUA and lower level of HDL-C （P 〈 0.05 ）. （2） AlP and SUA increased and were positively related with the severity of coronary lesions among the three sub-groups （ r = 0. 356 and r = 0. 300, P 〈 0.05 ）. AIP was higher in the sub-group of multiple coronary stenoses than in the control group （P 〈 0.05） , and no difference existed between any other sub-group and the control group （ P 〉 0.05 ）. SUA was higher in any sub-group than in the control group （ P 〈 0.05 ） , and there were no difference among the sub-groups （ P 〉 0.05 ）. （3） Logistic regression analysis showed that SUA is the related risk factor for AMI （ P 〈 0.05）. Conclusion AlP and SUA significandy increase in patients with AMI, and are positively related to severity of AMI.
出处
《临床军医杂志》
CAS
2013年第4期334-337,共4页
Clinical Journal of Medical Officers
关键词
急性心肌梗死
血浆致动脉硬化指数
血尿酸
acute myocardial infarction
atherogenic index of plasma
serum uric acid
