摘要
噬菌体是地球上最为丰富的生命形式,也是多样性最丰富的天然基因库,在长期进化过程中,噬菌体形成了多种非常有效的转录调节机制来利用宿主系统获得自身基因的表达.依据基因组是否具有RNA聚合酶编码基因,目前对少数模式细菌噬菌体的研究发现,其基因的转录调节可分为三种类型.然而,对于大多噬菌体特别是非裂解性噬菌体来说,对其基因转录调节机制的认识还十分有限.结合基因组学、转录组学和蛋白组学的研究方法,深入研究噬菌体基因的转录调节机制,揭示噬菌体基因转录调节机制的多样性和规律性,有助于进一步认识噬菌体与宿主之间的相互关系,为研究病毒的起源和进化提供参考.
Phages are the most abundant life form in the biosphere and the phage gene pool is the largest source of natural gene diversity. Phages have evolved various and highly effective regulation mechanisms of transcription to exploit resources of their hosts to redirect the host gene expression machinery to serve the needs of the phage gene expression. Based on the presence or absence of phage - encoded RNA polymerase, three main regulation strate- gies of gene transcription used by several model bacterial phages were uncovered. However, our understanding of regulation strategies utilized by most phages, especially by lysogenic phages, is relatively limited. Combined tech- niques in genomics, trancriptomics and proteomics could be used to study the regulation strategies of transcription of more phages to uncover their diversity and regularity, which will contribute to further understanding of the phage - host interactions and provide references for the study of the origins and evolution of phages.
出处
《昆明理工大学学报（自然科学版）》
CAS
北大核心
2013年第2期84-87,共4页
Journal of Kunming University of Science and Technology(Natural Science)
基金
国家自然科学基金资助(30960022
31160035
31260034)
关键词
细菌噬菌体
转录
RNA聚合酶
调节机制
bacteriophage
transcription
RNA polymerase
regulation mechanism
