摘要
目的观察糖皮质激素对慢性阻塞性肺疾病急性发作期患者的焦虑、抑郁的影响。方法选择2010年5月至2012年10月我院56例确诊为AECOPD的患者，随机分为实验组29例和对照组27例，实验组给予糖皮质激素治疗。观察两组患者焦虑、抑郁症状评分及发生情况。结果实验组患者激素治疗后，肺功能、血气分析情况好转，但抑郁和焦虑症状评分均有所增加。两组患者治疗2周后，实验组患者的抑郁和焦虑症状评分均高于对照组，差异有显著性（P〈0．05），实验组焦虑抑郁患者占72．4％，对照组仅44．4％，差异有统计学意义（X2=4，52，P〈0．05）。结论慢性阻塞性肺疾病急性发作期患者本身常伴随焦虑和抑郁症状，糖皮质激素类药物的应用可能加重患者的焦虑抑郁症状。
Objective To observe and analyze the effects of glucocorticoid application to anxiety and depression status of patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods From May 2010 to October 2012, 56 cases diagnosed in our hospital for AECOPD were randomly divided into experimental group （29 patients） and control group （27 patients）. The experimental group was treated with glucocorticoid treatment while the control group not. We observed two groups with anxiety and depression symptom scores and the occurrence. Results After treatment, lung function situation improved. After hormone therapy, patients in the experimental group with symptoms of depression and anxiety ratings had increased. After 2 weeks＇ treatment, the experimental group patients with depression and anxiety symptom scores were higher than those of the control group, the difference was statistically significant （P〈0.05）, the experimental group anxiety and depression in patients （72.4%）, while the control group was only 44.4%, and the difference was statistically significant （X2=4.52, P〈0.05）. Conclusion AECOPD patients originally have symptoms of anxiety and depression, and with the application of glucocorticoid drugs, the incidence of symptoms of anxiety and depression may increase.
出处
《国际医药卫生导报》
2013年第8期1096-1098,共3页
International Medicine and Health Guidance News
关键词
糖皮质激素
AECOPD
焦虑抑郁
Glucocorticoid
Acute exacerbation of chronic obstructive pulmonary disease （AECOPD）
Anxiety and depression
