摘要
目的 :观察高血浓度茶碱对心律失常的影响 ,探索安全合理使用茶碱方法。方法 :收集 194例住院治疗的病例 ,测定其血液茶碱浓度及作心电图检查 ,并按血浓度分为高浓度组 (A组 )和治疗浓度组 (B组 ) ,同时选择 56例未使用氨茶碱者作对照组 (C组 )。结果 :A组及B组引起窦性心动过速发生率分别为 57.7%、39.85% ,房纤及房扑发生率分别是 4 4 .4 %、2 .15% ,房性早搏发生率分别为 4 4 .4 %、4 .30 % ,室性早搏分别为 2 6 .6 %、4 .3% ,A组猝死率 2 .2 %。结论 :高血浓度茶碱患者发生严重心律失常、猝死的发生率比治疗浓度组显著升高 ,因此在使用氨茶碱时 ,特别是静脉应用 ,要严密监测茶碱血浓度 ,减轻茶碱对心脏的影响。
Objective:To observe the influences of high blood concentration of theophylline on arrhythmia. Method:The theophylline concentrations in blood from 194 patients were determined and their electrocardiograms were taken. These patients were divided into two groups:the high concentration group (group A) and the treatmental concentration group (group B),according to their theophylline concentrations in blood. 56 cases,who were aminophylline free,were used as control (group C). Results:The incidences of sinus tachycardia,atrial fibrillation and atrial flutter,atrial premature beats and ventricular premature beats in group A and group B were 57 7% and 39.85%,44.4% and 2.15%,44.4% and 4.3%,26.6% and 4.3% respectively. The sudden death rate in group A was 2.2%. Conclusion:The incidences of severe arrhythmia and sudden death in patients with high blood concentration of theophylline were significantly higher than that in patients with treatmental concentration. The blood concentration of theophylline should then be closely monitored when aminophylline is used,especially intravenously used.
出处
《广州医学院学报》
2000年第2期38-40,共3页
Academic Journal of Guangzhou Medical College
关键词
氨茶碱
心律失常
茶碱血浓度
心律失常
Aminophylline
Arrhythmia
Blood theophylline concentration
