摘要
目的 :研究细胞间粘附分子 1(ICAM 1)在原发性肝癌的临床意义。方法 :以免疫组化方法结合全自动图像分析检测ICAM 1在 30例原发性肝癌组织及 6例正常肝组织的表达 ,分析其与肿瘤分化程度、大小及转移之间的关系。结果 :30例原发性肝癌组织 2 5例ICAM 1表达阳性 (阳性率 83.3% ) ,肝癌组织中ICAM 1含量明显高于正常肝组织 (P <0 .0 1) ,转移组肝癌中ICAM 1含量明显高于无转移组 (P <0 .0 1) ,而与年龄、性别、肿瘤大小、分化程度无关。结论 :原发性肝癌组织高度表达ICAM 1,检测ICAM 1有可能作为预测肝癌转移状态的一个指标。
Purpose: To study the expression and significance of intercellular adhesion molecule-1 (ICAM -1) in human hepatocellular carcinoma(HCC). Methods: Immunohistochemical location of ICAM-1 was performed on 30 liver tissue sections of patients with HCC and 6 normal liver tissues. Results: The expression of ICAM-1 was positive (25/30,83.3%) in the cell of hepatoma.Positive staining was honeycomb-like appearance in part of cases. Tissue ICAM-1 was higher in liver cancer than in normal tissue (P< 0.01 ). Tissue ICAM-1 was higher in liver cancer with metastasis than in liver cancer without metastasis (P<0.01). No correlation was found between tissue ICAM-1 and age or sex or tumor grade or tumor diameter. Conclusion: Enhanced ICAM-1 expression was found on hepatoma tissues. ICAM-1 may be a marker of presuming the metastasis of HCC patitents.
出处
《临床消化病杂志》
2000年第4期173-174,共2页
Chinese Journal of Clinical Gastroenterology
