摘要
目的探讨重组人生长激素联合肠内营养对围手术期肝硬化大鼠肝功能的影响。方法将32只肝硬化肝部分切除术后雄性Wistar大鼠随机分为对照组、肠内营养组(EN组)、生长激素组(GH组)、肠内营养联合生长激素组(EN+GH组),每组8只,5天后检测各组大鼠血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、白蛋白(ALB)。结果 EN+GH组血清ALB水平均高于GH组、EN组及对照组,P均<0.05,差异均有显著统计学意义;GH组、EN组血清ALB水平均显著高于对照组,P均<0.05,差异均有显著统计学意义;EN+GH组血清AST、ALT水平均显著低于对照组,P均<0.05,差异均有显著统计学意义。EN组血清AST、ALT水平均低于GH组,P均<0.05,差异均有显著统计学意义,但EN+GH组血清AST、ALT水平与EN组比较,P均>0.05,差异均无显著统计学意义。结论肠内营养联合重组人生长激素有改善肝硬化大鼠肝功能的作用,且在改善低蛋白血症的作用优于各药单独使用,但在降酶方面的作用与肠内营养药物单独使用无显著差别。
Objective To investigate the effects of growth hormone combined with enteral nutrition on liver function in rats with liver cirrhosis during perioperative period. Methods Total of 32 Wistar male rats with liver cirrhosis after partial hepatectomy were divided into four groups randomly： the control group, enteral nutrition （EN） group, growth hormone （GH） group, enteral nutrition combine with growth hormone （EN ＋ GH） group. Each group was comprised of eight rats. The liver function： albumin （ALB）, alanine aminotransferase （ALT）, aspartate aminotransferase （AST） were determined 5 days later. Results For EN ＋ GH group, the serum level of ALB is higher than that of the other three groups （all P 〈 0.05）, the serum levels of AST, AST were lower than those of the control group （all P ~ 0.05）. The serum levels of AST, ALT of EN group were lower than those of GH group （all P 〈 0.05）, but there were no difference between EN ＋ GH group and EN group （all P ~ 0.05）. Conclusions Growth hormone combined with enteral nutrition can improve the liver function of cirrhotic rat, and the hypoproteinemia effect is superior to each drug used alone, while the enzyme reducing effect had no significant difference compared with enteral nutrition used alone.
出处
《中国肝脏病杂志（电子版）》
CAS
2013年第1期42-45,共4页
Chinese Journal of Liver Diseases：Electronic Version
关键词
肝硬化
肠道营养
生长激素
围手术期
大鼠
Liver cirrhosis
Enteral nutrition
Growth hormone
Perioperative period
Rats
