摘要
目的探讨超声引导下经皮穿刺药物注射治疗肝癌并发肾上腺转移瘤的临床应用价值。方法在11例肝癌并发肾上腺转移瘤(15个病灶)患者,采用在超声引导下经皮穿刺注射碘化油表阿霉素乳剂治疗。肿瘤位于右侧肾上腺4例,左侧肾上腺3例,双侧肾上腺4例。肿瘤大小为3.3～11cm,平均直径6.6cm,其中11个病灶肿瘤直径小于5cm,4个病灶肿瘤直径大于5cm。结果对单个转移瘤治疗平均2.8次,治疗后随访6个月。按照RE-CIST评价标准,在直径小于5cm的11个肿瘤,获得部分应答、疾病稳定和疾病进展分别为7个、3个和1个;在直径大于5cm的4个病灶中,则分别为1个、2个和1个;15个病灶客观有效率为53.3%。结论在超声引导下经皮穿刺注射碘化油表阿霉素乳剂治疗肝癌并发肾上腺转移瘤是微创、安全、有效和价格低廉的治疗方法。
Objective To evaluate the efficacy of percutaneous injection under ultrasonography guildance of emulsion of llipiodol and epirubicin in treatment of patients with hepatocellular carcinoma and adrenal metastases. Methods 11 patients with hepatocellular carcinoma and adrenal metastases were included in this study,and among them,there were 4 cases with right,and 3 with left and 4 with bilateral adrenal metastases. Tumor diameters were between 3.3em to 11em with the average diameter of 6.6cm. All patients received epirubicin injection（6mg/cm） with 21G needle under ultrasonography guildance at the interval of 21 days. Results Each patients had an average treatment of 2.8 times,and they were all followed-up for 6 months. Based on the response evaluation criteria in solid tumors,the partial response,stable disease and progressive disease were 7,3 and 1 in 11 metastases tumors with diameter less than 5cm,and the PR, SD and PD were 1,2 and 1 in 4 metastases tumors with diameter larger than 5cm;the rate of objective response was 53.3% （8/15）. Conclusion Percutaneous injection under ultrasonography guildance of emulsion of llipiodol and epirubicin in the treatment of patients with hepatocellular carcinoma and adrenal metastases is effective, safe and cheap.
出处
《实用肝脏病杂志》
CAS
2013年第2期147-149,共3页
Journal of Practical Hepatology
