摘要
目的探讨高血压早期肾损害检测血清胱抑素C(Cyst-C)、尿微量白蛋白/肌酐(UA/Cr)比值和内皮素-1(ET-1)的诊断价值。方法选择血肌酐(Cr),尿素氮(BUN)正常的原发性高血压患者96例(高血压组)及非高血压患者69例(对照组)。按肾动态显像是否正常分别将2组各分为肾功能正常组和早期肾损害组,均进行血清Cyst-C、ET-1及尿UA/Cr比值测定,观察各组血清Cyst-C、ET-1及尿UA/Cr的变化。结果 1)高血压组血清Cyst-C、ET-1及尿UA/Cr比值均高于对照组(均P<0.05),并随血压升高而明显增高。2)高血压组患者尿UA/Cr比值阳性率为51.04%,血清Cyst-C阳性率为63.54%,尿UA/Cr联合血清Cyst-C检测阳性率为78.13%,尿UA/Cr联合血清Cyst-C检测阳性率较单项检测阳性率明显升高(均P<0.05)。3)高血压组中肾功能正常组Cyst-C、ET-1及尿UA/Cr比值与对照组中肾功能正常组比较差异均无统计学意义(均P>0.05);高血压组中早期肾损害组Cyst-C、ET-1、尿UA/Cr比值均高于对照组中早期肾损害组(均P<0.05)。结论 Cyst-C联合尿UA/Cr比值检测有助于高血压肾病的早期诊断,而ET-1水平升高可能是高血压早期肾损害的原因之一。
Objective To evaluate the diagnostic value of serum cystatin-C （Cyst-C）,urinary albumirdcreatinine ratio （UA/Cr） and endothelin-1 （ET-1） in early renal damage induced by hypertension. Methods Ninety-six patients with primary hypertension and 69 patients without hypertension who had normal levels of serum creatinine and urea nitrogen were selected as hypertension group and control group, respectively. According to the dynamic renal imaging, all of them were divided into normal renal function group and early renal damage group. The Cyst-C, ET-1 and UA/Cr were detected. Results The Cyst-C and ET-1 levels and UA/Cr in hypertension group were significantly higher than those in control group and obviously increased with elevated blood pressure （all P〈0.05）. The positive rate of combined Cyst-C and UA/Cr detection in hypertension patients was significantly higher than that of either alone （78.13% vs 63.54% and 78.13% vs 51.04%, respectively; P〈0.05）. There were no significant differences in Cyst-C, ET-1 and UA/Cr in patients with normal renal function between hypertension group and control group（all/）〉0.05）. However, Cyst-C and ET-1 levels and UA/Cr in patients with hypertension and early renal damage were obviously higher than those in patients with early renal damage alone （all P〈0.05）. Conclusion The combined detection of Cyst-C and UA/ Cr contributes to the early diagnosis of hypertensive kidney disease. The elevation of ET-I levels may be a cause of early renal damaze induced by hypertension.
出处
《实用临床医学（江西）》
CAS
2013年第2期21-24,共4页
Practical Clinical Medicine
