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HTK液在冠状动脉搭桥手术中的应用 被引量：2

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摘要 目的通过对比组氨酸—色氨酸—酮戊二酸(HTK)液及含血停搏液在体外循环下冠状动脉搭桥术(CABG)中的应用,探讨HTK液在CABG中的使用方法及其心肌保护效果。方法将60例单纯行CABG的患者随机分为两组,HTK组术中使用HTK液正灌+逆灌的方法进行灌注停跳和心肌保护,对照组则使用常规的4∶1冷血高钾停搏液。在麻醉诱导后、升主动脉开放心脏复跳后10 min及术后6、12、24、48 h分别采血检测心肌肌钙蛋白T(cTnT)和肌酸激酶同工酶(CK-MB),并比较两组术后心脏自动复跳情况、后并行循环辅助时间、血管活性药物使用情况和术后心功能等指标。结果 HTK组心脏自动复跳率高于对照组、后并行循环辅助时间短于对照组(P均<0.05);两组的cTnT和CK-MB浓度在升主动脉开放后均逐步升高,与升主动脉阻断前相比,P<0.05,12 h达高峰,24 h后逐渐下降;HTK组cTnT和CK-MB的上升幅度在各时点均小于对照组(P均<0.05)。结论在CABG手术中,HTK液正灌+逆灌的方法能够获得较好的心肌保护效果,其心肌保护效果优于冷血停搏液。
作者 王凯 孔祥荣 周巍 朱宇翔 王金山
机构地区 天津医科大学三中心临床学院
出处 《山东医药》 CAS 2013年第15期58-60,共3页 Shandong Medical Journal
关键词 组氨酸-色氨酸-酮戊二酸液 冠状动脉搭桥术 心肌保护 心肌肌钙蛋白T 肌酸激酶同工酶
分类号 R961 [医药卫生—药理学] R544.3 [医药卫生—心血管疾病]
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参考文献9

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二级参考文献32

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山东医药
2013年 第15期

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