摘要
肝缺血再灌注损伤是肝脏外科手术及肝移植中常见的病理生理现象,损伤过程涉及到很多重要机制,如微循环障碍、细胞凋亡、炎症因子的释放等。而在这应激过程中发现肝细胞内HSP70表达明显增高,有研究结果表明HSP70直接或间接参与了肝脏组织的保护和再生,提高动物模型中肝大部分切除后动物的生存率,其中涉及到了很多机制。本综述阐述HSP70在肝缺血再灌注损伤中的保护机制,进一步研究其保护机制对减少肝外科手术后肝组织的损伤有着重要意义,对临床疾病治疗也有着很重要的意义。
Hepatic ischemia-reperfusion injury is common pathological physiology phenomenon in liver surgery and liver transplantation. This process involves a lot of important mechanisms, such as microcirculation disturbance, cell apoptosis, inflammation factors release and so on. Simultaneously, in these process we found that intracellular HSP70 expression is increased obviously. Some research shows that HSP70 involved in directly or indirectly the hepatocyte protection and regeneration and improve animals survival after 95% liver resection, which involve a lot of mechanism. The review show how to alleviate liver ischemia-reperfusion injury when HSP70 is at high level, further study about the mechanism of protection will help to reduce liver tissue damage after liver surgery .It is also significance in clinic.
出处
《中外医学研究》
2013年第11期148-150,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
