摘要
目的：探讨腹腔引流导管联合吉非替尼控制癌性胸水的疗效。方法：以15例老年肺腺癌所致中量以上的胸腔积液患者为研究对象，所有患者均应用腹腔引流导管行胸腔闭式引流，同时予吉非替尼250mg，口服，1次，d。结果：15例患者均一次置管成功，2例导管阻塞用肝素稀释液3ml冲管后再通；1例导管脱落，1例导管外脱引流不畅重新置管，1例出现气胸经健侧卧位引流管抽气后吸收。经导管胸腔内注入高聚金葡素1—3次。所有患者经5～10d置管，胸腔积液引流彻底。7例维持服药胸水完全控制；8例因药费高相继停药，胸水控制时间4～18个月。结论：腹腔引流导管闭式引流安全、损伤小，缓解症状迅速，联合吉非替尼长期控制癌性胸水疗效明确，但吉非替尼因费用高难以长期维持应用。
Objective： To explore the efficacy peritoneal drainage catheter combined with gefitinib to control malignant pleural effusion. Methods： 15 elderly patients with lung adenocarcinoma patients with a large amount of pleural effusion in patients as research subjects. All patients underwent peritoneal drainage catheter closed thoracic drainage, while giving gefitinib 250 mg, orally, once/d. Results： 15 patients were first catheter successful, 2 cases of catheter obstruction with heparin diluents 3 ml red tube recanalization; 1 case the catheter off and decathlete, 1 patient pneumothorax contralateral supine drainage pipe exhaust and after cure. Through the catheter to inject high poly staphylococci 1 to 3 times, all patients by 5 to 10 days of catheterization, and thorough drainage of pleural effusion.7 patients remained medication, pleural effusion complete control, 8 patients with high drug costs before and after stop medication, pleural effusion control time 4 to 18 months.Conclusion： Closed drainage of the abdominal catheter is a safe, method of injury, relieve symptoms quickly, Combined with gefitinib, the long-term control of malignant pleural effusion efficacy is clear. Due tothe highcost of gefitinib difficuh to maintain long-term application.
出处
《中外医学研究》
2013年第11期11-12,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
腹腔引流导管
吉非替尼
肺腺癌
胸腔积液
Peritoneal drainage catheter
Gefitinib
Lung adenocarcinoma
Pleural effusion
