摘要
目的探讨参附对大鼠失血性休克后早期炎症反应的抑制作用。方法将30只Wistar大鼠随机分为3组,每组10只,分别为空白对照组(A组)、失血休克模型组(B组)和参附治疗组(C组)。采用ELISA测定血清中IL-1β、IL-6、IL-10和TNF-α的浓度。结果 B组和C组血清IL-1β、IL-6、IL-10和TNF-a明显高于A组(P<0.01);B组和C组大鼠相比较,血清IL-1β、IL-6和TNF-α的含量增加,IL-10的含量降低,差异均有统计学意义(P<0.01)。结论参附可有效降低失血性休克后炎症因子的产生。
Objective To investigate the Shenfu inhibition of early inflammatory response after hemorrhagic shock in rats. Methods 30 Wistar rats were randomLy divided into three groups（n=10）, the control group （A）, hemorrhagic shock model group （B） and Shenfu treatment group （C group）. The concentration of IL-1 β, IL-6, IL-10 and TNF- α was tested by ELISA. Results The serum IL-1β, IL-6, IL-10 and TNF-α of group B and group C was significantly higher than that in group A （P〈0.01）; Compared to group B and group C, serum IL-1 β, IL-6 and TNF-α content increased and IL-10 content decreased, the differences were statistically significant （P〈0.01）. Conclusion Shenfu can effectively reduce the production of inflammatory cytokines after hemorrhagic shock.
出处
《当代医学》
2013年第12期28-29,共2页
Contemporary Medicine
关键词
休克
出血性
炎症因子
参附
Shock
Hemorrhagic
Inflammatory factor
Shenfu
