摘要
目的分析山东省泰安市2011年1月至12月儿童手足口病(HFMD)的临床流行病学特征。方法对1406例手足口病患儿的临床资料进行临床流行病学和病原学分析。结果 1406例患儿中男938例,女648例;年龄<1岁56例(3.98%),1～3岁1036例(73.68%),3～6岁252例(17.92%),>6岁56例(3.98%)。手足口病疫情全年均有报告,5～7月为高峰期,7月达最高峰,11月为全年第2高峰,1月最低。989例经外周血EV71-IgM和咽拭子DNA-PCR法进行病原学检测,EV71阳性248例(24.07%),CoxA16阳性505例(51.06%)。轻症病例998例,重症病例351例。1121(80.07%)并发心肌损害,295例(21.07%)并发肺炎,51例(3.64%)并发肝功能损害。351例重症病例中,脑膜炎、脑炎333例,脑脊髓炎9例,肺水肿5例,循环障碍4例;痊愈339例,后遗症10例,死亡2例。结论 HFMD的早期发现、及时诊断、有效治疗可改善预后。
Objective To analyze the epidemiological and clinical characteristics of children with hand-foot-mouth disease（HFMD）in Taian area during 2011.Methods A total of 1046 cases were retrospectively investigated for epidemiological information and clinical features.Results Of the 1406 children with HFMD,938 were male and 648 were female.Fifty-six cases（3.98%）were less than 1 year old,1036 cases（73.68%）were 1-3 years old,252 cases（17.92%）were 3-6 years old and 56 cases（3.98%） were older than 6 years old.The prevalent peak was from May to July.Pathogens were analyzed in 989 cases by periphery blood EV71-IgM antibodies assay and DNA-PCR testing of throat swab specimens.Two hundred and forty-eight cases（25.07%）EV71 were positive,505 cases（51.06%）CoxA16 were positive.There were 998 mild cases and 351 severe cases.One thousand one hundred and twenty-one cases（80.07%） with cardiac damage,295 cases（21.07%）with pneumonia,51 cases（3.64%）with hypohepatia.Of the 351 severe cases,there were 333 cases with meningitis or encephalitis,9 cases with encephalomyelitis,5 cases with pulmonary edema and 4 cases with disturbance of circulation;Three hundred and thirty-nine cases were recovered,10 cases with sequelae,2 cases died.Conclusion The prognosis of HFMD is good if the disease could be early discovered,diagnosed and managed.
出处
《临床医学》
CAS
2013年第2期28-30,共3页
Clinical Medicine
关键词
手足口病
流行病学
儿童
Hand-foot-mouth disease
Epidemiology
Children
