摘要
肝硬化失代偿期就是肝硬化晚期，一般指肝硬化发展到一定程度，超出肝功能的代偿能力，临床有明显的病理变化。主要表现为肝功能损害、门脉高压、脾大、腹水、上消化道出血，常规治疗以抗感染、止血、纠正凝血机制等为主，肝硬化晚期急性上消化道出血患者易发生失血性休克甚至死亡，是消化内科急诊危重病症之一。临床上抢救肝硬化失代偿期急性出血患者时，很多情况下不能合理用血，基本上是以输注全血或红细胞为主，不仅浪费了大量血液，同时也会严重影响治疗效果。笔者与临床医师共同观察，认为在抢救大出血患者时应充分认识大量输血和常规输血的不同之处，特别是凝血异常问题。因此应合理应用各种血液成分，特别是冷沉淀凝血因子与新鲜冰冻血浆，再配合其他措施才能达到更好的治疗效果。
To investigate the effect of fresh frozen plasma and cryoprecipitate on the treatment of liver cirrhosis patients at decompensation stage with hematemesis. After infusion of fresh frozen plasma and cryoprecipitate, we observed the clinical manifestation and detected blood routine, coagulating time, plasma fibrinogen levels and fibroneetin levels before and after therapy. Compared to blood transfusion,infusion of fresh frozen plasma and cryoprecipitate decreased coagulating time,improved the coagulation parameters,and had better efficacy of hemosatasis. Besides blood transfusion,infusion of fresh frozen plasma and cryoprecipitate would be an alternative treatment for liver cirrhosis patients at decompensation stage.
出处
《临床血液学杂志（输血与检验）》
CAS
2013年第2期276-277,共2页
Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)
关键词
肝硬化失代偿期
呕血
新鲜冰冻血浆
冷沉淀
liver cirrhosis decompensation stage
hematemesis
fresh frozen plasma
cryoprecipitate
