摘要
目的:分析多囊卵巢综合征(PCOS)患者行体外受精-胚胎移植(IVF-ET)的结局及其影响因素。方法:对2010年1月～2011年10月在唐山市妇幼保健院生殖遗传科经预处理后行IVF-ET的PCOS不孕患者70周期和因输卵管因素行IVF-ET的159周期进行回顾性分析,比较两组患者的年龄、体重指数(BMI)、Gn起始剂量、Gn总量、Gn天数、HCG日的E2值、获卵数、MⅡ卵率、受精率、着床率及临床妊娠率。结果:PCOS组患者的Gn起始剂量、Gn总量小于对照组,Gn天数大于对照组(P<0.05);HCG日的E2值、获卵数高于对照组(P<0.05),但MⅡ卵率低于对照组;受精率、着床率、临床妊娠率与对照组相比无统计学差异(P>0.05)。结论:IVF-ET是难治性PCOS不孕的有效方法。
Objective： To analyze in vitro fertilization - embryo transfer （ IVF - ET） outcome and influencing factors in patients with polycystic ovary syndrome （PCOS） . Methods： Seventy IVF- ET cycles in infertile patients with PCOS and 159 IVF- ET cycles in infertile patients because of tubal factors who were pretreated in the hospital from January 2010 to October 2011 were analyzed retrospective- ly; the ages, body mass indexes （BMI） , initial doses of gonadotropin, the total doses of gonadotropin, the administration days of gonadotro- pin, the levels of estradiol on the day of human chorionic gonadotropin （HCG） injection, the numbers of retrieved oocytes, the ratios of M ]I oocytes, fertilization rates, implantation rates, and clinical pregnancy rates in the two groups were compared. Results： The initial dose and total dose of gonadotropin in PCOS group were statistically significantly lower than those in control group, while the administration day of gon- adotropin in PCOS group was statistically significantly longer than that in control group （ P 〈 0. 05 ） ; the level of estradiol on the day of HCG injection and the number of retrieved oocytes in PCOS group were statistically significantly higher than those in control group （ P 〈 0. 05 ） , but the ratio of M II oocytes in PCOS group was statistically significantly lower than that in control group ; there was no statistically significant difference in fertilization rate, implantation rate, and clinical pregnancy rate between the two groups （ P 〉 0.05 ） . Conclusion ： IVF - ET is an effective method for treatment of refractory infertility induced by PCOS.
出处
《中国妇幼保健》
CAS
北大核心
2013年第11期1772-1773,共2页
Maternal and Child Health Care of China
