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肾性贫血患者血清Hepcidin表达的临床意义及相关性分析 被引量：1

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摘要 目的探讨体内铁稳态平衡的重要调节分子Hepcidin在肾性贫血患者体内的表达,以及血清Hepcidin与机体慢性炎症,体内铁存储之间的关联性,研究血清Hepcidin对肾性贫血患者的影响,提供改善肾性贫血的可行性分析。方法采用酶联免疫法(ELISA)测定75例肾性贫血组和30例正常对照组的血清Hepcidin和IL-6水平,以及检测HBG含量、尿素氮,肌酐及铁蛋白等指标,进行分析,研究其相关性和临床意义。结果血清Hepcidin的表达水平随着贫血程度的加重增高,各组与正常对照组比较都有统计学差异(P<0.05),并且各组间两两比较也有统计学差异(P<0.05)。肾性贫血组的血清Hepcidin的表达与血清铁蛋白、IL-6呈正相关,有显著相关性(P<0.05);与贫血程度呈负相关,有显著相关性(P<0.05)。结论肾性贫血时,血清Hepcidin的升高可能与慢性肾功能不全的慢性炎症状态,体内铁代谢失衡,存贮铁释放抑制有关,从而为改善肾性贫血提供了新的思路。
作者 韩长鸣 段前梅
机构地区 扬州大学附属江都市人民医院
出处 《齐齐哈尔医学院学报》 2013年第5期630-632,共3页 Journal of Qiqihar Medical University
关键词 HEPCIDIN 肾性贫血
分类号 R341 [医药卫生—基础医学]
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参考文献13

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二级参考文献25

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齐齐哈尔医学院学报
2013年 第5期

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