摘要
为研究慢性阻塞性肺疾病(COPD)患者血清中IL-27的浓度,并进一步探讨IL-27与COPD患者肺功能之间的相关性,为COPD病情严重程度的检测及疗效判断提供一定的依据。纳入30例急性加重期和稳定期COPD患者,28例健康体检者,采集外周静脉血用酶联免疫吸附法(ELISA)测定血清中IL-27的浓度。分别测定肺功能,对COPD组血清IL-27的浓度与肺功能指标进行相关分析。COPD急性加重期、稳定期与对照组血清中IL-27浓度分别为(177.29±28.29)pg/mL、(104.80±44.55)pg/mL、(65.46±32.07)pg/mL,3组中血清IL-27浓度均不同,差异有统计学意义(F=73.58,P<0.001)。COPD急性加重期、稳定期血清IL-27含量均高于对照组,COPD急性加重期血清IL-27含量高于COPD稳定期,COPD急性加重期患者血清IL-27含量与FEV1%、FEV1/FVC呈负相关(相关系数r分别为-0.605,-0.601,P<0.001)。IL-27在COPD患者血清中的水平升高提示在COPD发病机制中可能发挥着一定作用。
To Study the IL-27 concentration in the serum of patients with COPD,and further explore the correlation between IL-27 and lung function of COPD patients,so as to provide a certain basis for the detection of COPD severity and evaluation of therapeutic efficiency.Methods：30 patients with COPD in acute exacerbation period and stable period,and 28 healthy persons were chosen,and enzyme-linked immunosorbent assay（ELISA） was used to test pulmonary function,and to analyze the correlation between the IL-27 concentration and lung function in COPD group.Results：The concentrations of IL-27 in acute exacerbation period group,stable period group and control group were（177.29±28.29） pg/mL,（104.80±44.55） pg/mL,（65.46±32.07） pg/mL,respectively.The IL-27 in three groups were different,and the difference was statistically significant（F=73.58,P0.001）.IL-27 concentrations in acute exacerbation period group,stable period group were higher than the control group;IL-27 concentration in acute exacerbation period group was higher than stable period group;IL-27 concentration in acute exacerbation period group had negative correlation with FEV1% and FEV1/FVC（correlation coefficient was-0.605 and-0.601,respectively P0.001）.Conclusions：The serum IL-27 levels increase in patients with COPD may play a role in the pathogenesis of COPD.
出处
《石河子大学学报（自然科学版）》
CAS
2013年第1期73-76,共4页
Journal of Shihezi University(Natural Science)
