摘要
目的研究高频双向对称方波对神经的选择性兴奋影响,对实现特定直径范围神经的兴奋具有重要的意义,并为功能神经电刺激的临床应用提供更多信息。方法以在体动物的坐骨神经为研究对象,建立神经选择性刺激模型。首先使用高频双向对称方波进行实验,通过改变高频双向对称方波后测试脉冲出现的延迟时间或者高频双向对称方波的频率,得出经高频刺激后兴奋神经所需的阈值,从而实现神经的选择性兴奋。然后将对称方波刺激波形变为非对称方波2:1、非对称方波3:1后进行重复实验。结果用高频双向方波实现了神经的选择性兴奋,并对比了在对称方波、非对称方波2:1、非对称方波3:1三种不同刺激波形下对神经的选择性兴奋的效果,得出了最佳的刺激模式。结论三种刺激波形的刺激模式下,选用电荷平衡的非对称方波3:1实现的神经选择性兴奋最佳。
Objective To investigate selective nerve activation of high frequency biphasic electrical current using the symmetric and asymmetric square wave biphasic pulses. The study aimed to find an optimal waveform stimulus pattern for the selectively stimulating nerve fibers effectively. This study can provide more information for the clinical applications of electrical nerve block. Methods We used the sciatic nerve of live animals as the research object and established neural selective stimulation model. This paper presented biphasic pulse modes respectively with different pulses including symmetric square wave, asymmetric square wave 2： 1, asymmetric square wave 3：1 stimulus waveform,which can selectively stimulate nerve fibers effectively. Resultswe obtained the best stimulation waveform, through the comparison of the selective nerve activation consequents in the three electrical stimulation modes. Conclusions The asymmetric square wave 3：1 stimulation mode is the optimal waveform stimulus pattern.
出处
《北京生物医学工程》
2013年第2期117-121,共5页
Beijing Biomedical Engineering
基金
国家自然科学基金(30872860)
北京市自然科学基金(3122011)资助
关键词
神经
选择性刺激
双向脉冲
动物实验
nerve
selective stimulation
biphasic pulse
animal experiment
