摘要
Gene chip is the fusion of molecular biology,microelectronics and micromechanics.Mask board is the key to high-density gene chip fabrication.By using masks ,DNA probes can be synthesized in situ with high density and accurate location.But it is costly to make the masks.A method of chip optimization is proposed to reduce the number of masks needed for gene chip synthesis,to reduce the synthesiscycles,and then to increase the efficiency of chip making.It is very important to gene chip applications.
Gene chip is the fusion of molecular biology,microelectronics and micromechanics.Mask board is the key to high-density gene chip fabrication.By using masks ,DNA probes can be synthesized in situ with high density and accurate location.But it is costly to make the masks.A method of chip optimization is proposed to reduce the number of masks needed for gene chip synthesis,to reduce the synthesiscycles,and then to increase the efficiency of chip making.It is very important to gene chip applications.
出处
《生物技术》
CAS
CSCD
2000年第4期42-46,共5页
Biotechnology
基金
国家自然科学基金资助课题!(6 99710 10 )
