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ADDl磷酸化位点错义突变与非贲门胃癌易感性的关联研究 被引量：1

A missense SNP in the codon of ADD1 phosphorylation site associated with non-cardia gastric cancer
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摘要 目的探讨ADDl磷酸化位点错义突变与中国人群非贲门胃癌的易感性。方法结合蛋白磷酸化位点数据库（PhosphoSitePlus）和SNP数据库（dbSNP），筛选出ADDl基因磷酸化位点错义突变，通过TaqMan分型方法检测1998例非贲门胃癌病例和2008例正常对照中错义突变的基因型。采用Logistic回归模型分析各基因型患者非贲门胃癌的发病风险。结果找到了位于ADDl第586位磷酸化位点密码子上的错义突变rs4963。对照组中CC、CG和GG基因型频率分别为25．2％、50．4％和24．4％，病例组分别为20．1％、50．6％和29．3％，两组差异有统计学意义（P〈0．001）。与rs4963CC基因型相比，CG基因型和GG基因型非贲门胃癌的发病风险显著升高（OR=1．24，95％C／为1．06～1．46，P=0．008；OR=1．49，95％C／为1．25～1．78，P〈0．001）。结论ADDl基因的磷酸化位点错义突变rs4963可能是非贲门胃癌的遗传易感因素。
出处 《中华肿瘤杂志》 CAS CSCD 北大核心 2013年第4期311-314,共4页 Chinese Journal of Oncology
关键词 胃肿瘤 基因 ADDl 单核苷酸多态 易感性 磷酸化
分类号 R644 [医药卫生—外科学]
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参考文献18

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中华肿瘤杂志
2013年 第4期

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