摘要
目的探讨肺炎支原体(MP)感染与小儿支气管哮喘发病的相关性,为临床治疗支气管哮喘提供依据。方法收集67例支气管哮喘患儿作为观察组,选择同期治疗的上呼吸道感染患儿49例作为对照组,两组患儿分别采用被动凝集法检测血清肺炎支原体抗体(MP-IgM),同时采用放射免疫法测定哮喘患儿的血清总IgE,并对各数据分析比较。结果观察组患儿血清MP-IgM阳性28例,阳性率为41.79%;对照组患儿中有6例血清MP-IgM阳性,阳性率为12.24%,两组患儿血清MP-IgM阳性率比较差异有统计学意义(P<0.01);观察组MP-IgM阳性患儿的血清总IgE水平明显高于MP-IgM阴性患儿的血清总IgE水平,两组比较差异有统计学意义(t=3.278,P<0.01);观察组MP-IgM阳性患儿的外周血嗜酸性粒细胞计数(EOS)明显高于MP-IgM阴性患儿的EOS,两组比较差异有统计学意义(t=2.965,P<0.01)。结论肺炎支原体感染是小儿支气管哮喘(发作)的重要原因,肺炎支原体感染与小儿支气管哮喘存在相关性,对哮喘急性发作期患儿应当行实验室检查以明确诊断,指导临床合理治疗。
OBJECTIVE To determine the relationship between bronchial asthma in children and Mycoplasma pneumoniae infection in order to provide basis for the treatment of bronchial asthma.METHODS A total of 63 children with bronchial asthma were selected as the experiment group,49 children with acute upper respiratory infection as the control group.The MP-IgM antibody level was determined by particle agglutination method in both groups,and total serum IgE level of the bronchial asthma group was determined by isotope radioimmunoassay,the data were analyzed and compared.RESULTS Totally 28 cases were determined as Mp-IgM positive in the bronchial asthma group,6 cases in the control group,the positive rates of Mp-IgM were 41.79% and 12.24% respectively,there was statistical difference between the two groups（P0.01）.The total serum IgE level was significantly higher in the MP-IgM positive bronchial asthma children than in the MP-IgM negative bronchial asthma children,the difference was statistically significant（t=3.278,P0.01）.The peripheral blood eosinophil counts（EOS） level was significantly higher in the MP-IgM positive bronchial asthma children than in the MP-IgM negative bronchial asthma children,the difference was statistically significant（t=2.965,P0.01）.CONCLUSION There is close relationship between Mycoplasma pneumoniae infection and bronchial asthma in children.The laboratory test should be done routinely for the asthmatic patients at the acute stage so as to provide data for the diagnosis and treatment.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第8期1975-1977,共3页
Chinese Journal of Nosocomiology
关键词
肺炎支原体
小儿
支气管哮喘
Mycoplasma pneumoniae
Children
Bronchial asthma
