摘要
目的研究胺碘酮联合迷走神经刺激法对于心律失常(主要为快速性心律失常)的疗效。方法将2009年至2011年心内科及急诊科收治的快速型心律失常的患者264例随机分成3组,分别使用单纯胺碘酮治疗、单纯迷走神经刺激治疗以及胺碘酮联合迷走神经刺激治疗的方法进行治疗。记录患者心率转复的时间以及转复后的心率,同时对患者进行12个月的随访,观察患者的复发以及远期并发症发生率。结果胺碘酮组转复率为77.3%,平均转复时间为(52.5±10.3)min;迷走神经组转复率为35.2%,平均转复时间为(11.5±4.7)min;联合组转复率为83.0%,平均转复时间为(23.5±6.2)min。联合组的转复率显著高于其余两组且平均转复时间较短,差异具有显著性(P<0.05)。此外胺碘酮组与联合组中房扑/颤、交界性、室性、室上性心动过速以及室扑/颤的转复率较高,且显著高于迷走神经组,其差异均具有统计学意义(P<0.05)。结论胺碘酮联合迷走神经刺激对于快速性心律失常的控制治疗具有转复效好、转复时间短的特点,此外其对室上性与室性心动过速的疗效更好。对于其他方法无法控制的顽固性室上性、室性心律失常可尝试使用此法治疗。
Objective To observe the effects of amiodarone combined with vagal nerve stimulation （VNS） in patients with arrhythmia. Methods A total of 264 patients treated in the Department of Cardiology and Department of Emergency in the hospital from 2009 to 2011 were randomly divided into amiodarone group, VNS group and combined treatment （amiodarone plus VNS） group. The time of heart beat recovery and heart rate after treatment were recorded and patients were followed up for 12 months to observe the recurrence and complication. Results Amiod- atone group： the conversion rate was 77.3% with average recovery time （52.5 ＋ 10.3 ） rain; VNS group： the conversion rate was 35.2% with average recovery time （ 11.5 ＋4.7） min; combination group： the conversion rate was 83.0% with average recovery time （23.5 ~6.2） min. The conversion rate was significantly higher in combination group than those in amiodarone group and ~NS group （ P 〈 0.05 ） and the average recovery time was relatively short. In addition, combination group and amiodarone group had higher conversion rate than VNS group for AF, AVNRT, VF, SVT and VT （ all P 〈 0.05）. Conclusion Higher conversion rate and short recovery time can be obtained by the combined treatment of amioda- rene with VNS in arrbythmia patients particularly those with ventricular and supraventricular taehycardia. It may be used when other treatments fail to work.
出处
《临床和实验医学杂志》
2013年第8期597-598,共2页
Journal of Clinical and Experimental Medicine
关键词
心律失常
胺碘酮
迷走神经刺激
AiThythmia
Amiodarone
Vagal nerve stimulation
