摘要
目的探讨狼疮肾炎(lupus nephritis,LN)患者治疗方案与病理分型的关系。方法选取2006年～2011年期间怀化医专附属怀化市第三人民医院收治的49例系统性红斑狼疮(systemic lupus erythematosus,SLE)伴肾损害的患者,均行肾活检证实为LN。分析病理类型,比较予肾上腺皮质激素(激素)联合免疫抑制剂治疗前后的临床指标。结果肾活检结果分别为Ⅰ型3例、Ⅱ型8例、Ⅲ型6例、Ⅳ型17例、Ⅴ型11例、Ⅵ型4例。对比每组中治疗前后的血尿素氮、血肌酐、血沉、血清C3、尿蛋白量五项临床指标均有统计学意义(P值分别为0.022,0.031,0.005,0.000,0.014);对比各组之间治疗后的血尿素氮、血肌酐、血沉、血清C3、尿蛋白量五项临床指标均无统计学意义(P>0.05)。结论 LN的病理类型以Ⅳ型和Ⅴ型居多。三组的治疗效果相当,可见激素联合免疫抑制剂对各型LN的治疗效果良好。
Objective To investigate the relationship between therapy and pathological type of lupus nephritis patients. Methods Totally 49 SLE patients with renal damage in our hospital from 2006 to 2011 were selected. All were proven LN after renal biopsy. Analyze the pathological type and the change of clinical indicators after the treatment of adrenal cortical hormone combined with Immunosuppressant. Results There were 3 cases oftype Ⅰ, 8 cases of type Ⅱ,6 cases of type Ⅲ, 17 cases of type Ⅳ, 11 cases of type Ⅴ, 4 cases of Ⅵ. Compared with the clinical indicators of each group before and after treatment, there were significant differences （P〈0.05）.However, there was no significant difference in the clinical indicators after treatment between each group（P〉0.05）. Gonclusion Most of the pathological type of LN are type Ⅵ and type V .The curative effect of three group are similar. The curative effect of adrenal cortical hormone combined with Immunosuppressant for LN is fine.
出处
《当代医学》
2013年第10期33-35,共3页
Contemporary Medicine
关键词
狼疮肾炎
治疗
病理
Lupus nephritis
Therapy
Pathology
