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乳腺癌血管内皮细胞生长因子-C及其受体-3的表达及临床作用 被引量：3

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摘要 乳腺癌是女性常见的恶性肿瘤之一，可发生淋巴管内皮细胞及淋巴管的增生。乳腺癌早期主要经淋巴道转移，淋巴结受累程度是一个关键的预后指标。血管内皮细胞生长因子（VEGF）-C是第一个被发现的淋巴管生成因子，其受体VEGFR-3是毛细淋巴管内皮细胞特异性的标志物，VEGF—C与VEGFR-3特异性的作用于淋巴管内皮细胞的生长因子，它可以诱导淋巴内皮细胞增殖、迁徙，并形成淋巴窦，并且与肿瘤细胞的区域淋巴结转移密切相关㈦。本研究拟通过对乳腺癌组织中VEGF—C与VEGFR-3表达的检测。旨在探讨其与乳腺癌临床分期和淋巴结转移之间的关系及其临床意义。
作者 陈润琦
机构地区 山西省肿瘤医院乳腺中心
出处 《中国药物与临床》 CAS 2013年第4期496-497,共2页 Chinese Remedies & Clinics
关键词 血管内皮细胞生长因子-C 乳腺癌组织 临床作用 淋巴管内皮细胞 VEGFR-3 受体 区域淋巴结转移 淋巴管生成因子
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献6

  • 1Makinen T,Veikkola T,Mustjoki S,et al. Isolated lymphatic en- dothelial cellstransduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. EMBO,2001,20(17): 4762-4773.
  • 2谢永红,杜月光,许敬尧,马时荣,王桂华.VEGF-C在乳腺癌诊断中的意义[J].诊断病理学杂志,2003,10(4):251-252. 被引量：3
  • 3Jussila L,Alitalo K. Vascular growth factors and lymphangiogen- esis. Physiol Rev,2002,82(3):673-700.
  • 4Kinoshita J, Kitamura K, Kabashina A, et al. Clincal signifcance of vascular endothelial growth factor-C (VEGF-C) in breast can- cer. Breast Cancer Res Treat,2001,66(2) : 159-164.
  • 5Skobe M,Hawighorst T,Jackson DG,et al. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metasta- sis. Nature Medicine,2001,7(2) : 192-198.
  • 6Stacker SA,Williams RA,Achen MG. Lympbangiogenic growth factors as markers of tumor metastasis. APMIS,2004,112(7-8) : 539-549.

二级参考文献12

  • 1[1]Kinoshita J,Kitamura K,Kabashima A et al.Clinical significance of vascular endothelial growth factor-C(VEGF-C) in breast cancer.Breast Cancer Res Treat,2001,66:159
  • 2[2]Spigel DR,Burstein HJ.HER2 overexpressing metastatic breast cancer.Curr Treat Options Oncol,2002,3:163
  • 3[3]Camp RL,Rimm EB,Rimm DL.Met expression is associated with poor outcome in patients with axillary lymph node negative breast carcinoma.Cancer,1999,86:2259
  • 4[5]Jeltsch M,Kaipainen A,Joukov V et al.Hyperplasia of lymphatic vessels in VEGF-C transgenic mice.Science,1997,276:1423
  • 5[6]Mandriota SJ,Jussila L,Jeltsch M et al.Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumor metastasis.EMBO,2001,20:672
  • 6[7]Yonemura Y,Endo Y,Fujita H et al.Role of vascular endothelial growth factor C expression in the development of lymph node metastasis in gastric cancer.Clin Cancer Res,1999,5:1823
  • 7[8]Kurebayashi J,Otsuki T,Kunisue H et al.Expression of vascular endothelial growth factor (VEGF)family members in breast cancer.Jpn J Cancer Res,1999,90:977
  • 8[9]Jussila L,Alitalo K.Vascular growth factors and lymphangiogenesis.Physiol Rev,2002,82:673
  • 9[10]Furudoi A,Tanaka S,Kitadai Y et al.Clinical significance of vascular endothelial growth factor C expression and angiogenesis at the deepest invasive site of advanced colorectal carcinoma.Oncology,2002,62:157
  • 10[12]Cao Y,Linden P,Farnebo J et al.Vascular endothelial growth factor C induces angiogenesis in vivo.Proc Natl Acad Sci USA,1998,95:14389

共引文献2

同被引文献35

  • 1Tamura M,Oda M,Tsunezuka Y,et al.Chest CT and serum vascular endothelial growth factor-C level to diagnose lymph node metastasis in patients with primary non-small cell lung cancer[J].Chest,2004,126(2):342.
  • 2Jiang J T,Zhang L F,Zhou B,et al.Relationships of u PA and VEGF expression in esophageal cancer and microvascular density with tumorous invasion and metastasis[J].Asian Pac J Cancer Prev,2012,13(7):3379.
  • 3Liu M W,Su M X,Zhang W,et al.Effect of Melilotus suaveolens extract on pulmonary microvascular permeability by downregulating vascular endothelial growth factor expression in rats with sepsis[J].Mol Med Rep,2015,doi:10.3892/mmr,2015:3146.
  • 4Hu J,Cheng Y,Li Y,et al.microRNA-128 plays a critical role in human non-small cell lung cancer tumourigenesis,angiogenesis and lymphangiogenesis by directly targeting vascular endothelial growth factor-C[J].Eur J Cancer,2014,50(13):2336.
  • 5Ciobanu M,Eremia I A,et al.Lymphatic microvessels density,VEGF-C,and VEGFR-3 expression in 25 cases of breast invasive lobular carcinoma[J].Rom J Morphol Embryol,2013,54(4):925.
  • 6Ciobanu M,Eremia I A,et al.Lymphatic microvessels density,VEGF-C,and VEGFR-3 expression in 25 cases of breast invasive lobular carcinoma[J].Rom J Morphol Embryol,2013,54(4):925.
  • 7刘钊,周斌,赵坚,胡晔,朱昌生,张毅.VEGF-C在非小细胞肺癌血清及淋巴液中的表达及意义[J].现代中西医结合杂志,2009,18(4):357-359. 被引量：6
  • 8石臣磊,秦华东,石铁锋.乳腺癌并发甲状腺癌的超声诊断价值[J].医学临床研究,2010,27(7):1216-1218. 被引量：3
  • 9宋海云,陈登庭,董守义.乳腺癌术前及术后血清VEGF-C水平变化及临床意义[J].细胞与分子免疫学杂志,2010,26(9):903-904. 被引量：2
  • 10程秀永,郝志成,万玉.甲状腺激素对新生大鼠脑组织血管内皮细胞生长因子表达的影响[J].实用儿科临床杂志,2011,26(8):596-597. 被引量：1

引证文献3

二级引证文献12

中国药物与临床
2013年 第4期

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