摘要
目的探讨螺内酯对慢性心力衰竭患者心率变异性及左室重构的影响。方法选取86例慢性心力衰竭患者,随机分为常规治疗组和螺内酯组,测定治疗前及治疗3月后24h平均正常R-R间期标准差(SDNN)、24h连续5min节段平均正常R-R间期标准差(SDANN)及连续正常R-R间期差的均方根(rMSSD),采用超声诊断仪测定左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)的变化。结果螺内酯组患者的心率变异性指标SDNN、SDANN及rMSSD明显增加,左心重构指标LVEDD、LVESD明显下降,LVEF明显上升(P<0.05)。结论螺内酯能够有效改善慢性心力衰竭患者的心率变异性及改善左室重构。
Objective To observe the changes of heart rate variability （HRV）, ventricular remodeling parameters after intervention with spironolactone. Methods Eighty-six patients with CHF were randomly assigned to conventional therapy group and spironolactone group, HRV and cardiac function parameters were measured before and 3 months after in- tervention. Results After 3 months of therapy, SDNN,SDANN,rMSSD and LVEF were all improved in spironolactone group,LVEDD,LVESD were reduced in spironolactone group （P 〈 0. 05 ）. Conclusions Spironolactone can obviously improve HRV and ventricular remodeling in CHF patients.
出处
《实用老年医学》
CAS
2012年第4期317-318,322,共3页
Practical Geriatrics
关键词
螺内酯
心力衰竭
心率变异性
左室重构
spironolaetone
heart failure
heart rate variability
ventricular remodeling
