摘要
急性早幼粒细胞性白血病(APL)常因严重出血等症状导致患者死亡,曾是各型白血病中最凶险的一型。1971年初哈尔滨医科大学附属第一医院在世界上首次采用亚砷酸(ATO)治疗急性早幼粒细胞白血病,使之成为各型白血病中治疗效果最好的一型。然而砷剂的毒副作用一直很受人们关注,这也是亚砷酸在欧美一些国家应用受限制的重要原因之一。
Acute promyelocytic leukemia (APL) is the most dangerous subgroup in leukemia because of the severe haemorrhage and other complications, which usually resulted in the high mortality in patients. In 1971, arsenic trioxide(ATO) proved to be significantly effective for APL in the First Affiliated Hospital of Harbin Medical University for the first time all over the world. Therefore, ATO gained a more encouraging efficacy for APL than for other subgroups. However, we focus on its side effects and toxicities ,which restrict the use of ATO in some countries of Europe and America.
出处
《临床药物治疗杂志》
2013年第2期52-55,共4页
Clinical Medication Journal
基金
黑龙江省高等学校科技创新团队建设计划项目(2010td07)
黑龙江省哈尔滨市科技创新人才研究专项资金项目(2001RFQYS082)
哈医大一院科研基金(2012B07)
关键词
急性早幼粒细胞白血病
亚砷酸
分化综合征
acute promyelocytic leukemia
arsenic trioxide differentiation syndromet