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难治性颞叶癫痫患者脑组织中Vav3的表达

Brain expression of Vav3 in patients with medically intractable temporal lobe epilepsy
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摘要 目的研究难治性颞叶癫痫患者脑组织中Vav3的表达，探讨其在难治性颞叶癫痫形成中的意义。方法应用免疫组织化学法检测难治性颞叶癫痫患者脑组织和正常脑组织中Vav3蛋白的表达。光学显微镜下观察Vav3蛋白表达结果，并对免疫组织化学结果进行分析。结果免疫组化检测发现Vav3蛋白在难治性颞叶癫痫患者脑组织中阳性表达率明显高于正常脑组织，两组相比差异具有统计学意义（x^2=15．841，P〈0．015。实验组患者海马组中Vav3染色评分2分和3分占总体的76．93％（10／13），而在颞叶组中Vav3染色评分1分和2分占总体的64．71％（11／17），可见在难治性颞叶癫痫患者海马组织较颞叶组织神经元中Vav3的表达明显增强。结论Vav3在难治性颞叶癫痫患者的海马和颞叶脑组织中表达增强，提示其有可能参与了难治性颞叶癫痫的形成。
作者 徐春晶 姚丽芬 吕萍 许芳 刘菲
机构地区 哈尔滨医科大学附属第一医院神经内科
出处 《神经疾病与精神卫生》 2013年第1期75-77,共3页 Journal of Neuroscience and Mental Health
关键词 癫痫 颞叶 Vav3 免疫组织化学 Epilepsy, temporal lobe Vav3 Immunohistochemistry
分类号 R742.1 [医药卫生—神经病学与精神病学]
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参考文献12

  • 1Dong Z, Liu Y, Lu S, et al. Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer [J]. Mol Endocrinol, 2006,20 (10) : 2 315-2 325.
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二级参考文献7

  • 1Zhong YD,Yin L,Shan L,et al.Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer[J]. Molecular Endocrinology ,2006,20( 10 ):2315-2325.
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神经疾病与精神卫生
2013年 第1期

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