摘要
吸入给药是防治哮喘、慢性阻塞性肺疾病等呼吸道疾病的首选给药方式。常见的吸入给药制剂包括压力定量吸入剂、干粉吸入剂和雾化吸入剂。吸入给药有效的评价指标为粒径的测定,测定吸入制剂粒径的方法主要有撞击器法和光学仪器法。就目前吸入给药制剂的优点、剂型分类、体外评价和研究现状等进行综述。
Inhalation administration is the first choice for the treatment of respiratory diseases,such as asthma and chronic obstructive pulmonary diseases（COPD）.In clinic,the most common used dosage forms for inhaled drug administration are pressurized metered-dose inhalation,dry powder inhalation,and atomizing inhalation.The in vitro effective evaluation index of inhalation is particle size,and the determination of particle size could be carried out with the impactors method and the optical instruments method.This review discusses the characteristic,classification,research status,and in vitro evaluation methods of inhalation preparation.
出处
《现代药物与临床》
CAS
2013年第2期232-235,共4页
Drugs & Clinic
基金
国家重大新药创制专项(2011ZX09-401-009
2011ZX09201-101-19
2012ZX09105102)
天津市科技支撑项目(09ZCKFSH01200)
关键词
吸入给药
哮喘
慢性阻塞性肺疾病
体外评价
inhalation administration
asthma
chronic obstructive pulmonary diseases
in vitro evaluation
