A facile synthesis of the oxazolidinone antibacterial agent linezolid

A facile synthesis of the oxazolidinone antibacterial agent linezolid

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摘要 A facile synthetic route of linezolid 1 has been developed. Using commercially available （R）- epichlorohydrin as the starting material, 1 was obtained through a sequence of cyclization, substitution, a Goldberg coupling, aminolysis and acetylation reactions. The synthetic route is easy to perform and can be scaled up. A facile synthetic route of linezolid 1 has been developed. Using commercially available （R）- epichlorohydrin as the starting material, 1 was obtained through a sequence of cyclization, substitution, a Goldberg coupling, aminolysis and acetylation reactions. The synthetic route is easy to perform and can be scaled up.

作者 Yan-Wu Li Yan Liu Yun-Can Jia Jian-Yong Yuan

机构地区 Institute of Life Science & Pharmacy College

出处《Chinese Chemical Letters》 SCIE CAS CSCD 2013年第3期230-232,共3页 中国化学快报（英文版）

基金 supported by Natural Science Foundation Project of CQ CSTC

关键词 LinezolidSynthesisGoldberg coupling reaction LinezolidSynthesisGoldberg coupling reaction

分类号 TQ465 [化学工程—制药化工]

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Chinese Chemical Letters

2013年第3期

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A facile synthesis of the oxazolidinone antibacterial agent linezolid

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