摘要
An efficient two-step method was described for the synthesis of chromeno[3＇,4＇：5,6]pyrano[2,3-blindole derivatives. The three-component reaction of 4-hydroxycoumarin, variously substituted benzaldehydes and indolin-2-one was promoted by P205 in refiuxing ethanol to give trimolecular adducts, which were then cyclized in 1,2-dichloroethane under reflux using POCI3.
An efficient two-step method was described for the synthesis of chromeno[3＇,4＇：5,6]pyrano[2,3-blindole derivatives. The three-component reaction of 4-hydroxycoumarin, variously substituted benzaldehydes and indolin-2-one was promoted by P205 in refiuxing ethanol to give trimolecular adducts, which were then cyclized in 1,2-dichloroethane under reflux using POCI3.
基金
the National Natural Science Foundation of China(No.21176222)
Zhejiang Key Innovation Team of Green Pharmaceutical Technology for financial support
