摘要
目的考查海豹油脂肪乳的稳定性。方法采用GC法测定海豹油脂肪乳中EPA、DPA、DHA的含量,并考察脂肪乳的pH、游离脂肪酸值和过氧化值,以表征其化学稳定性;以粒径和电位变化为指标考察其物理稳定性;同时,开展配伍稀释试验、影响因素试验、加速试验以及长期留样试验。结果海豹油脂肪乳与注射用水和5%葡萄糖注射液在10 h内有良好配伍稳定性,但与NaCl射液混合后乳滴粒径显著增大,两者不适宜配伍使用。影响因素试验表明海豹油脂肪乳对高温、冷冻和强光均敏感。在(25±2)℃避光条件下进行的加速试验和在(4±2)℃避光条件下进行的长期留样试验显示,海豹油脂肪乳各项指标基本无变化,稳定性良好。结论海豹油脂肪乳在25℃和4℃下放置6个月稳定,应避光贮存,不得冷冻。
Objective To investigate the stabilities of seal oil based lipid emulsions（SOLE）.Methods The contents of main fatty acids EPA,DPA and DHA were measured by GC.The pH variation and values of free fatty acid and peroxidation were monitored,and the particle size and zeta potential of the emulsion were determined by TEM（Transmission electron microscopy） and zetasizer,respectively.Dilution experiments,influential factor experiments,accelerated trials [（25± 2）℃,preventing from light）,and long-term tirals（4±2）℃,for 6 months] were carried out to investigate the chemical and physical stabilities of the seal oil based lipid emulsions.Results The results of dilution experiments showed that injection of water and glucose had insignificant effects on the lipid emulsions in 10 hours,however,injection of sodium chloride led to obvious increase in particle size.The color of the emulsions changed to some extent under lamplight or elevated temperature while no obvious change in particle size was observed.However,the particle size increased evidently when the emulsions were frozen.The results of the accelerated and long-time trials showed all the measuring parameters kept unchanged,which suggested the emulsion was stable under the proper storing conditions.Conclusion The seal oil based lipid emulsion is stable for at least 6 months at room temperature or in 4 ℃ fridge,avoiding light,heating and freezing.
出处
《广东药学院学报》
CAS
2013年第1期16-20,共5页
Academic Journal of Guangdong College of Pharmacy
基金
科技部国际科技合作与交流专项项目(2008DFA31080)
关键词
海豹油
脂肪乳
稳定性
seal oil
lipid emulsion
stabilities
