摘要
目的探讨阿托伐他汀对充血性心衰(CHF)患者血清胱抑素C(CysC)、心肾及炎性指标的影响。方法选取2010年3月-2012年2月于南京市胸科医院进行治疗的58例充血性心衰患者为研究对象,将其根据随机数字表法分为对照组(常规治疗组)和观察组(阿托伐他汀组)每组各29例,将两组患者治疗前及治疗后4周、8周的血清CysC、心肾及炎性指标进行比较。结果观察组治疗后4周及8周的血清CysC及炎性指标均低于对照组,而心肾指标改善幅度也大于对照组,且治疗后8周上述指标均优于治疗后的4周,P均<0.05,差异均有统计学意义。结论阿托伐他汀可显著改善CHF患者CysC、心肾功能及炎性指标,可全面改善患者机体的综合状态。
Objective To study the influence of atorvastatin on the level of serum cystatin C（CysC）,cardiac and renal function,inflammatory indexes of patients with congestive heart failure（CHF）.Methods Total 58 patients with congestive heart failure in our hospital from March 2010 to February 2012 were selected as research object,and they were divided into control group（routine treatment group） and observation group（atorvastatin group） with 29 cases in each group according to random number table,then the serum CysC,cardiac and renal function,inflammatory indexes of two groups before and after the treatment at fourth and eighth week were compared.Results The serum CysC and inflammatory indexes of observation group after the treatment at fourth and eighth week were all lower than those of control group,improvement range of cardiac and renal function indexes were all bigger than those of control group,the difference were significant（P0.05）.Conclusion The atorvastatin can significantly improve the CysC,cardiac and renal function,inflammatory indexes of patients with CHF,and its comprehensive application value is higher.
出处
《中华全科医学》
2013年第4期542-542,588,共2页
Chinese Journal of General Practice
关键词
阿托伐他汀
CHF
CYSC
心肾功能
炎性指标
Atorvastatin
Congestive heart failure
Cystatin C
Cardiac function and renal function
Inflammatory indexes
