摘要
目的探讨全身弥散加权成像（WB—DWI）在恶性肿瘤骨转移诊断中的应用价值。方法对118例恶性肿瘤患者行WB—DWI检查，并于扫描后1周内对可疑骨转移部位行常规磁共振成像（MRI）／CT榆查。对资料进行统计学分析，比较单独应用WB—DWI、MRI／CT及二者联合应用（WB—DWI＋MRI／CT）对恶性肿瘤骨转移的诊断价值：分别测定骨转移组及良性骨病变组的表观弥散系数（ADC）值，探讨其在良恶性病变诊断中的价值。结果受试：E作者曲线（ROC）分析结果显示，WB—DWI＋MRI／CT诊断骨转移瘤的ROC曲线下而积、特异度、正确诊断指数及阳性预测值最高（0．999、100．0％、97．4％、100．0％），诊断效果最好；骨转移组平均ADC值[（0．71±0．15）×10^-3mm^2／s]明显低于良性骨病变组[（1．50±0．23）×10^-3mm^2／S1，差异具有统计学意义（F=261．587，P〈0．001）。结论WB—DWI是常规MRI／CT的有益补充，结合ADC值测定，在恶性肿瘤骨转移诊断与鉴别诊断方面具有一定价值。
Objective To investigate the application of whole-body diffusion-weighted imaging （WB-DWI）, and to detect hone metastasis in malignant tumor patients. Methods A total of 118 malignant tumor patients prospectively underwent WB-DWI, standard MRI/CT in suspicious bone metastases parts within one week after inspection. Final diagnosis of the bone metastases in each patient was determined on the basis of results of all radiologie and follow-up examinations. The differential diagnosis value of apparent diffusion coefficient （ADC） in benign and malignant bone metastases was compared with the variance analysis. Results Area under ROC curve value of WB-DWI with standard MRI/CT （0.999） was larger than that of WB-DWI （0.944） and standard MRI/CT （0.983）, and the specificity, accuracy and positive predictive value were also the highest（100.0 %, 97.4 %, 100.0 %）. The ADC values of malignant bone metastases were significantly lower than those of benign lesions[（0.71±0.15）×10^-3 mm2/s vs （1.50±0.23）x10 3 mm2/s] with a statistically significant difference（F = 261.587, P 〈 0.001）. Conclusion WB-DWI is the beneficial supplements of standard MRI/CT. Which can be used for assessment and differential diagnosis of bone metastases in malignant tumor patients combined with ADC value.
出处
《肿瘤研究与临床》
CAS
2013年第3期187-190,共4页
Cancer Research and Clinic
基金
山西省卫生厅科技攻关计划（200901）
关键词
肿瘤
磁共振成像
弥散
肿瘤转移
Neoplasms
Diffusion magnetic resonance imaging
Neoplasms metastasis
