摘要
目的：研究偏头痛患者血浆中一氧化氮（ＮＯ）和内皮素（ＥＴ）的含量变化。方法：应用经颅多普勒（ＴＣＤ）检测大脑中动脉（ＭＣＡ）峰值速度（Ｖｓ）；随机筛选５０例Ｖｓ增高的患者，抽取静脉血样，用硝酸还原酶法测定血浆中ＮＯ含量；用放免法测定ＥＴ含量。结果：偏头痛组与对照组比较血浆ＮＯ含量显著降低，ＥＴ含量增高（Ｐ＜０ ．０１）。结论：ＮＯ和ＥＴ含量在偏头痛发作时发生变化，与病变血管的数目有关，与病程无关，它们可能与脑血管舒缩功能障碍的发生有关。
Objective: To study the change of the levels of nitric oxide (NO) and endothelin (ET) in plasma of patients with migraine. Methods: Transcranial doppler (TCD) to measure the highest velocity (Vs). The levels of NO and ET in plasma of these patients can be detected with reductase method or RIA. Results: The NO levels in plasma of patients with migraine were lower than those in normal control partients evels, however, the ET were higher. Conclusion: The levels of NO and ET in plasma are changing when migraine happens. It can be affected by the number of ill blood vessels, not by the course of this diease. This may be related with the obstacle of dilate and contract function of cerebral blood vessels.
出处
《中国临床医学》
2000年第3期304-305,共2页
Chinese Journal of Clinical Medicine
关键词
偏头痛
TCD
一氧化氮
内皮素
Migraine Transcranial Doppler Nitric Oxide Endothelin
