摘要
目的：检验血清中可溶性细胞间粘附分子－１（Ｓｏｌｕｂｌｅ ｉｎｔｅｒｃｅｌｌｕｌａｒ ａｄｈｅｓｉｏｎ ｍｏｌｅｃｕｌｅ－ １， ｓＩＣＡＭ－１），观察脑缺血患者血清中 ｓＩＣＡＭ－１的变化规律。方法：采用Ｄｏｔ ｂｌｏｔｔｉｎｇ法检测脑缺血后不同时相、高危人群和健康人群血清中的浓度，结果进行方差分析。结果：脑缺血患者脑缺血８ｈ血清中ｓＩＣＡＭ－１的浓度增高，脑缺血２４ｈ浓度达到高峰，持续１５ｄ仍处于高水平。高危人群血清中ｓＩＣＡＭ—１浓度亦增高。结论：急性脑缺血患者和高危人群血清中ｓＩＣＡＭ—１增高，ｓＩＣＡＭ—１和脑缺血性疾病的发生、发展关系密切，将为诊断脑缺血提供一个新的指标。
Objective: To define the of serum sICAM - 1 levels after cerebral ischemia. Methods: Serum concentrations of sICAM -1 were tested at different time in 20 patients with acute ischemic stroke and compared with age - and sex - matched controls with (n = 20) and without (n = 20) vascular risk factors. The data were analyzed with various analysis. Results: Patients with acute stroke had increased level of sICAM - 1 at 8h, and reached peak level at 24h, and remained at a high level until 15d. People with vascular risk factors also had increased level of sICAM - 1. Conclusion: Soluble ICAM - 1 was up - regulated in patients with acute ischemic stroke and those with vascular risk factors. The high level of sICAM - 1 may have close relation with the ischemic stroke and be a new marker of the disease.
出处
《中国临床医学》
2000年第3期278-279,共2页
Chinese Journal of Clinical Medicine
