摘要
目的:探讨癸酸氟哌啶醇注射液与癸氟奋乃静注射液治疗慢性精神分裂症之疗效及不良反应。方法:将门诊129例慢性精神分裂症随机分为癸酸氟哌啶醇注射液治疗组(研究组)65例和癸氟奋乃静注射液治疗组(对照组)64例,疗程12周。采用简明精神病量表(BPRS)和副反应量表(TESS)在治疗前和治疗后第2、6、12周末进行疗效及不良反应评定。结果:治疗后癸酸氟哌啶醇注射液组和癸氟奋乃静注射液组总有效率分别为93.85%、93.75%,研究组总有效率虽然高于对照组但无显著性差异(P>0.05)。在治疗过程中及治疗后两组患者的症状评分均比治疗前有明显降低,差异具有统计学意义(P<0.05),但分别比较治疗中和治疗后两组间的症状评分,差异均不具有显著性(P>0.05)。结论:采用癸酸氟哌啶醇注射液与癸氟奋乃静注射液治疗慢性精神分裂症,可明显改善患者症状,提高治疗有效率,具有临床应用价值。
Objective ：To explore the efficacy and side effects of Haridol - D （Haloperidol Decanoate Injection）and Dijia - D （Fluphenazine Decanoate Injection） in the treatment of chronic schizophrenia. Methods ：129 cases of outpatients with chronic schizo- phrenic were divided randomly into Haridol - D group of 65 patients and Dijia - D group of 64 patients in cases, treatment 12 weeks. The curative effect and adverse reactions were assessed with BPRS and TESS. Before treatment and after treatment of 2w, 6w, 12w. Results： After treatment of 12w, the Haridol - D group and Dijia - D group total effective rate was 93.85% ,93.75%, the Haridol - D group total effective rate is higher than that of the Dijia - D group but without significant difference （ P 〉 0.05 ）. In the course of treatment and after treatment in two groups of patients with symptom score was significantly lower than that before treatment, the differ- ence was statistically significant （ P 〈 0.01 ）, but In the course of the treatment and after treatment were compared between the two groups in the symptom score, the differences were not significant （ P 〉 0.05 ）. Conclusions： The use of Haridol - D and Dijia - D treatment of chronic schizophrenia, can significantly improve symptoms, improve treatment efficiency, has the value in clinical application.
出处
《中国民康医学》
2013年第5期27-29,共3页
Medical Journal of Chinese People’s Health
