摘要
目的探讨溃疡性结肠炎伴抑郁患者5-羟色胺转运体启动区基因多态性的变化。方法将15例溃疡性结肠炎伴抑郁患者设为研究组，15例溃疡性结肠炎不伴抑郁患者设为对照组，应用聚合酶链反应技术检测两组5-羟色胺转运体启动区基因多态性的分布频率，并进行对比分析。结果研究组5-羟色胺转运体启动区的s／s基因频率显著高于对照组（P〈0．05），L／S及L／L基因频率均低于对照组，但两组比较差异无显著性（P〉0．05）。结论5-羟色胺转运体启动区基因的S／S基因型可能是溃疡性结肠炎伴抑郁患者的易感基因之一。
Objective To explore the correlation between ulcerative colitis （UC）patients with depression and serotonin transporter （SERT） promoter region gene polymorphisms. Methods Fifteen UC patients with depression were assigned to research group and 15 ones without to control group, distribution frequencies of SERT promoter region gene polymorphisms detected using the Polymerase Chain Reaction （PCR）, and contrastive analyses performed. Results The S/S gene frequency in SERT promoter region was significantly higher in research than in control group （P〈0.05） ; both L/S and L/I. frequency were lower in research than in control group, but differences were not significant （P〉0.05）. Conclusion S/S genotype in SERT promoter region may be one of predisposing genes of UC patients with depression.
出处
《临床心身疾病杂志》
CAS
2013年第2期97-98,共2页
Journal of Clinical Psychosomatic Diseases
