摘要
目的探讨胆囊化学性破坏的可行性、有效性和安全性。方法20只家兔随机分为3组 ,以不同浓度的酒精和十二烷基硫酸钠 (SDS)作为硬化剂灌注胆囊 ,破坏胆囊粘膜。结果Ⅰ组 (高浓度组 )硬化后5天胆囊粘膜全部坏死脱落 ,2周纤维组织增生活跃 ,胆囊腔缩小,4周后胆囊纤维化自截。Ⅱ组 (低浓度组 )反应较轻 ,纤维化程度较差 ,部分可见粘膜再生。Ⅲ组 (对照组 )无异常改变。三组间硬化后胆囊内径差别显著 (P<0.01)。硬化剂毒性反应轻微。结论胆囊化学性破坏简单易行 ,安全有效 ,尤其适用于高危患者。
Objective To explore feasibility,efficiency and safety of chemical ablation of the gallbladder.Method 20 rabbits underwent gallbladdre sclerotherapy with different concentration of ethanol and sodium dodecy sullfate(SDS).Result Group l(high concentration)showed that the gallbladder mucosa was necrosed and denuded after 5 days,the gallbladder lumen was obliterated by fibrous scar tissue after 4 weeks.No reepithelization was found in Group2(low concentration)and was somewhat less effective.Group 3 was normal.Comparing with all groups,the change of the internal diameter of gallbladder treated with sclerosants was significant(p<0.01).Sclerosants was with less toxic side effects.Conclusion Chemical ablation of the gallbladder was simple and feasible,safe nd effective,especially when applied to high-risk cholithiasis patients.
出处
《浙江临床医学》
2000年第10期655-656,共2页
Zhejiang Clinical Medical Journal
