摘要
目的 观察四逆汤对家兔膈肌疲劳的保护作用。方法 家兔乌拉坦麻醉,耳静脉注射油酸0.1ml/kg复制膈肌疲劳模型,剑突下分离膈肌条。分别记录膈肌收缩力及电活动变化。结果 腹腔注射四逆汤(2ml/kg)后可使正常家兔膈肌收缩力增加(P<0.01),膈肌放电积分曲线峰值(peak)、积分曲线斜率(slop)增加(P<0.01);复制膈肌疲劳后,腹腔注射四逆汤(2ml/kg),可使疲劳膈肌收缩力增加(P<0.01),peak值及slop值增加(P<0.01)。结论 四逆汤可使膈肌收缩力增加,电活动增强,对疲劳膈肌有保护作用。
Objective To observe protective effect of si-nitang on diaphragmatic fatigue in rabbits. Methods Anaesthetize rabbit with urethane and inject oleic acid to induce diaphagmatic fatigue. Then seperate diaphagm from xipha,record the changes of diaphagmatic contractiliti and electromyogram. Results After the administration of 2ml/kg of si-nitang on normal diaphragm.The contractility(P<0.01) ,peak and slop(P<0.01) were markedly increased. Injection si-nitang in 2ml/kg after fatigue could enhance recovery of the diaphragmatic fatigue. Conclusion Si-nitang sen increase the diaphragmatic contractility and electromyogram, showing protective effect on diaphragmatic fatigue.
出处
《中国基层医药》
CAS
2000年第5期348-349,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
四逆汤
膈肌疲劳
膈肌电图
膈肌收缩性
Si-nitang Diaphragmatic fatigue Diaphragmatic electrogram Diaphragmatic contractility
