摘要
1型糖尿病 (type 1DM)是儿童期一种常见的慢性病 ,其病因未明。但 1型 DM的主效易感基因位于 HL A上现已成公认的事实 ,而且随着研究的深入 ,发现了该疾病与不同的等位基因的相关性 ,与 DR3和 DR4,以及 DQ分子 ,尤其 DQβ链 5 7位非天门冬氨酸和 DQα链的 5 2位精氨酸的作用。通过跨种族的人群研究已证实了易感基因与发病率的一致性关系 ,然而一致性的程度在各种族中的不同则说明了其它次效基因的作用 ,尚需进一步的研究。1型 DM的分子流行病学研究的进展必将为其病因学研究提供强有力的支持。
Type 1 diabetes mellitus is a common chronic disease in childhood, and its aetiology is unclear. But it was an accepted fact that the major susceptible genes were located on HLA. With the further research, the relationships with various alleles were found, such as, HLA DR 3, DR 4 and HLA DQ molecule. The across race population studies have proved the consistency between the frequency of susceptible allele and the incidence, but the fact of different extent of the association in various population groups suggested that the other secondary susceptible genes also had effect, which need further study. The molecular epidemiological of type 1 DM will provide strong support for the aetiology.
出处
《疾病控制杂志》
2000年第3期250-252,共3页
Chinese Journal of Disease Control and Prevention
