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单纯性无排卵性子宫内膜中ER、PR和Ki-67的表达分析

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摘要 目的:从发病机制和病理组织学角度探讨单纯性无排卵性子宫内膜与子宫内膜简单型增生的诊断标准与鉴别诊断,明确二者的界限和病理诊断工作中的误区,为临床治疗提供准确参考,防止误诊和过度治疗。方法:应用免疫组织化学法检测雌激素受体(ER)、孕激素受体(PR)和Ki-67 3种标记物在各组子宫内膜中的表达,在形态学的基础上进一步探讨两种子宫内膜病变的诊断和鉴别诊断。结果:各组子宫内膜ER表达差异无统计学意义(P>0.05);PR在单纯性无排卵性子宫内膜中表达较高(P<0.05);Ki-67在子宫内膜简单型增生中表达较高(P<0.05)。结论:无论在病理组织学上还是在PR与Ki-67的表达上两组病变比较差异均有统计学意义。病理诊断医生应当也能够将两者区分开来,以利于临床治疗工作正确合理地进行。
出处 《中国妇幼保健》 CAS 北大核心 2013年第10期1649-1651,共3页 Maternal and Child Health Care of China
基金 陕西省卫生厅科研基金〔2010C05〕
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