摘要
目的观察中药白驳方Ⅰ号、白驳方Ⅱ号辨证论治联合他克莫司软膏治疗白癜风的临床疗效,并探讨其对T细胞亚群的影响。方法选择符合纳入标准的病例,按2∶1比例随机分为治疗组和对照组,治疗组经辨证分为治疗Ⅰ组(气滞血瘀型)和治疗Ⅱ组(肝肾阴虚型),分别口服白驳方Ⅰ号、白驳方Ⅱ号,同时外用0.1%他克莫司软膏,对照组只外用他克莫司软膏,疗程为3个月。观察治疗组和对照组治疗前后的皮损面积,比较其疗效,并检测治疗组患者治疗前后的T细胞亚群,与30例健康对照比较。结果治疗组与对照组治疗后皮损面积比较有差异(P<0.05);治疗组患者总有效率为83.6%,优于对照组61.29%(P<0.05)。白癜风稳定期患者与正常人群T细胞亚群比较无差异,但进展期患者与正常人相比有显著差异,其CD3、CD4、CD4/CD8均低于正常人群,而CD8明显高于正常人群。经中药治疗后,进展期患者的T细胞亚群有正常化的趋势。结论中药白驳方Ⅰ号、白驳方Ⅱ号联合他克莫司软膏治疗白癜风疗效确切,其作用机制可能与中药对T细胞亚群的调节作用有关。
Objective To observe the effect of Baibofang I, Baibofhng II with tacrolimus ointment for the treatment of vitiligo, and explore their impact on T cell subsets. Methods Qualified cases were randomly divided into observation group and control group in accordance with the ratio of two to one, and the observation group were divided into observation group I （Qi stagnation and blood stasis type） and observation group II （liver-kidney yin deficiency type）. Besides tacrolimus 0.1% ointment, the two treatment groups were given oral Baibofang I and Baibofang II respectively, while control group only given topical tacrolimus 0.1% ointment for 3 months. The size changes of the lesions area before and after the treatment were compared, and the efficacy of the different groups was evalued. The T cell subsets of the observation groups was compared with healthy control group. Results At the end of treatment, the size change of the lesions area had a difference between the observation group and the control （P〈0.05）, the observation group total eff;ciency was 83.6%, better than the control group which was 61.29% （P〈0.05）. Laboratory tests showed that T cell subsets had no difference between stable vitiligo patients and normal population, but the level of CD3, CD4 and CD4/ CD8 in the progressing vitiligo patients were significant lower than the normal population, whereas the level of CD8 was significant higher than the normal population. After traditional Chinese medicine treatment, T-cell subsets of progressing vitiligo patients had a trend of normalization. Conclusion The effect of traditional Chinese medicine preparation Baibofang I, Baibofang II with tacrolimus ointment in the treatment of vitiligo is obvious, and its mechanism may be related to the regulation ofT cell subsets.
出处
《实用皮肤病学杂志》
2013年第2期107-109,共3页
Journal of Practical Dermatology
关键词
白癜风
辨证论治
他克莫司软膏
T细胞亚群
Vitiligo
Syndrome differentiation and treatment： Tacrolimus ointment
T cell second flock
