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骨钙素(OC)对糖代谢的影响及其活性调节 被引量：10

Effect of osteocalcin(OC) on glucose metabolism and the regulation of its activity
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摘要 骨钙素(osteocalcin,OC)是由成骨细胞合成和分泌的非胶原骨基质蛋白,在骨骼的发育中发挥重要作用。近年的研究发现,羧化不全骨钙素(uncarboxylated osteocalcin,ucOC)可以促进小鼠胰岛β细胞增殖、胰岛素分泌、改善胰岛素抵抗,对糖尿病和肥胖的发生具有抑制作用。临床研究中也发现骨钙素含量与空腹血糖、胰岛素浓度、体脂含量呈负相关。这些研究确立了骨钙素调节糖代谢的重要作用,对其机制的了解将为治疗糖尿病提供新的靶点。 Osteocalcin（OC） is a non-collagenous bone matrix protein synthesized by osteoblasts.It plays an important role in skeleton development.The latest studies found that uncarboxylated osteocalcin（ucOC） can promote pancreas β-cell proliferation,increase insulin secretion,improve insulin sensitivity and protect from diabetes and obesity.Clinical examinations also found that OC and fasting blood glucose,insulin concentration and fat mass were negatively correlated.These findings established an important role of OC in regulating energy metabolism and understanding its mechanism will provide a novel target for the treatment of diabetes mellitus.
作者 张尧 于明香
机构地区 复旦大学附属中山医院内分泌科
出处 《复旦学报（医学版）》 CAS CSCD 北大核心 2013年第2期242-245,共4页 Fudan University Journal of Medical Sciences
关键词 骨钙素(OC) 羧化不全骨钙素(ucOC) 羧化骨钙素(cOC) 糖代谢 osteocalcin（OC） uncarboxylated osteocalcin（ucOC） carboxylated osteocalcin（cOC） glucose metabolism
分类号 R336 [医药卫生—人体生理学]
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参考文献23

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二级参考文献17

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共引文献44

同被引文献70

  • 1刘红,廖二元,伍贤平.骨钙素与代谢性骨病[J].国外医学（内分泌学分册）,2004,24(4):239-240. 被引量：45
  • 2祝海宝,郭定宗,李家奎,杨世锦,周东海,杨雪.奶牛骨钙素基因的克隆与原核表达[J].中国奶牛,2007(9):2-5. 被引量：5
  • 3Lee NK,Sowa H, Hinoi E,et al. Endocrine reguletion of energy metabolism by the skeleton [J]. Cell, 2007, 130 (3) :456-469.
  • 4Kanazawa I, Yamaguchi T, Yamamoto M, et al. Serum os-teocalcin level is associated with glucose metabolism and atherosclerosis parmeters in type 2 diabetes mellitus[J]. J Clin Endocrinol Metab,2009,94(1):45-49.
  • 5Witttrant Y,Gorin Y,Woodreff K,et al. High d(+)glu- cose concentration inhibits RANKL-induced osteoclasto- genesis[J]. Bone,2008,42(6) :1122-1130.
  • 6Gerdhem P, Isaksson A, Akesson K, et al. Increased bone density and decreased bone turnover, but no evident alter- ation of fracture susceptibility jn elderly women with dia- bets mellitus [ J ]. Osteoporos Int, 2005, 16 ( 12 ) : 1506- 1512.
  • 7Lee NK, Sowa H, Hinoi E, et al, Endocrine regulation of energy metabolism by the skeleton [J]. Cell, 2007, 130 (3) :409-411.
  • 8Ferron M, McKee MD, Levine RL, et al. Intermittent in- jections of osteoealein improve glucose metabolism and prevent type 2 diabetes in mice[J]. Bone, 2012,50 (2): 568-575.
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  • 10Ducy P.The role of osteocalcin in the endocrine crosstalkbetween bone remodelling and energy metabolism[J].Diabetologia,2011,54(6):1291-1297.

引证文献10

二级引证文献23

复旦学报（医学版）
2013年 第2期

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