摘要
背景:国际上相关研究提示外周血中谷草转氨酶、谷丙转氨酶水平可作为心血管危险因素的新生物学标志物。目的:观察分析多民族间谷草转氨酶/谷丙转氨酶比值与冠脉粥样硬化严重程度的关系。方法:回顾性分析730例行冠状动脉造影患者的资料,其中汉族455例;回族51例;维吾尔族126例;哈萨克族63例;其他民族35例。按民族的不同进行分组,以Gensini积分对血管狭窄程度进行分析。比较各组谷草转氨酶与谷丙转氨酶比值与冠脉粥样硬化严重程度的关系。结果与结论:谷草转氨酶/谷丙转氨酶在不同民族间(P=0.415)分布差异无显著性意义。患者年龄、性别、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血糖、谷丙转氨酶、谷草转氨酶及谷草转氨酶/谷丙转氨酶在不同Gensini积分组间的分布差异有显著性意义。Spearman相关分析结果显示年龄、低密度脂蛋白胆固醇、谷丙转氨酶、谷草转氨酶、谷草转氨酶/谷丙转氨酶、血糖与Gensini积分呈显著正相关,高密度脂蛋白胆固醇与Gensini积分呈显著负相关。提示谷草转氨酶/谷丙转氨酶比值与在多民族人群中与冠状动脉粥样硬化严重程度呈显著正相关。
BACKGROUND： There is a growing clinical interest in aspartate aminotransferase （AST） and alanine aminotransferase （ALT） as novel biomarkers of cardiovascular risk factors. OBJECTIVE： To investigate the relationship between the ratio of AST/ALT and severity of coronary atherosclerosis in a multi-ethnic population. METHODS： Totally 730 adult patients, including 455 subjects of Han nationality, 126 of Uygur nationality, 63 of Kazakh nationality, 51 of Hui nationality, and 35 of other nationalities, who underwent coronary angiography for suspected or known coronary atherosclerosis were enrolled in the present study. And, the severity of coronary atherosclerosis was defined by the Gensini score. Relationship of the ratio of AST/ALTwith the severity of coronary atherosclerosis was investigated. RESULTS AND CONCLUSION： A significant difference in the level of AST/ALT was not found among the various ethnic groups. Age, gender, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting blood glucose, ALT, AST, and AST/ALT differed significantly among the subjects in the Gensini score quartile. Spearman correlation analyses indicated that the Gensini score was significantly positively associated with age, low-density lipoprotein cholesterol, fasting blood glucose, AST, ALT and AST/ALT, but negatively associated with high-density lipoprotein cholesterol. The AST/ALT was significantly associated with the severity of coronary atherosclerosis in the multi-ethnic population.
出处
《中国组织工程研究》
CAS
CSCD
2013年第7期1324-1330,共7页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金资助(81170180)~~
关键词
组织构建
组织构建临床实践
谷草转氨酶
谷丙转氨酶
冠状动脉病变
GENSINI积分
年龄
性别
低密度脂蛋白胆固醇
高密度脂蛋白胆固醇
血糖
国家自然科学基金
tissue construction
clinical practice of tissue construction
aspartate aminotransferase
alanineaminotransferase
aspartate aminotransferase/alanine aminotransferase
coronary artery disease
Gensiniscoring
age
gender
low-density Iipoprotein cholesterol
high-density lipoprotein cholesterol
blood sugar
theNational Natural Science Foundation of China
