摘要
目的 :为探讨胃癌组织中 p5 3蛋白表达和 PCNA评分之间的相关性。方法 :运用免疫组织化学L SAB方法 ,对 6 8例原发性胃癌组织进行标记。结果 :p5 3蛋白表达阳性率 45 .5 8% (31/6 8) ,PCNA评分值 2 .40 0±1.10 1。 p5 3阳性和 PCNA评分在组织学分级 级、无淋巴结转移者明显低于组织学分级 级、有淋巴结转移者 ,分别为 (P<0 .0 5、P<0 .0 1)。结论 :p5 3蛋白和 PCNA与胃癌的发生、发展密切相关 ,可能是反映胃癌生物学行为和预测预后的重要标记物。
Objective:To study the relationship between the expression of p53 oncoprotein and the scoring of PCNA in primary gastric cancer tissues.Methods:The samples were examined with immunohistochemical technic by LSAB in 68 cases of gastric cancer.The positive rate of p53 oncoprotein and the mean scoring of PCNA were significantly lower in histologically grade I without lymphnode metastases than those in grade Ⅲ with lymphnode metastases (P<0.05;P<0.01) . Results:The results suggested that the expressions of p53 oncoprotein and scoring of PCNA might be related to the development,progression and the prognosis of gastric cancer and that they are important markers in reflecting the biological behavior and prognosis of gastric cancer.Conclusion:There was a close relationship between p53 protein,PCNA and the development of gastric cancer,and they may be the important marker of the biological behavior and prognosis predictor of gastric cancer.
出处
《肿瘤研究与临床》
CAS
2000年第4期233-234,共2页
Cancer Research and Clinic
关键词
胃癌
P53蛋白
增生细胞核抗原
免疫组织化学
Gastric cancer
p53 oncoprotein
Proliferating cell nuclear antigen
Immunohistochemistry
