摘要
目的探讨E-钙黏附蛋白表达对判断乳腺癌及三阴性乳腺癌预后的意义。方法用随机数字法调取本院2003～2005年浸润性乳腺癌(浸润性小叶癌除外)280例,用免疫组化法检测E-钙黏附蛋白表达情况。Log Rank法对比生存曲线,分析E-钙黏附蛋白表达与乳腺癌及三阴性乳腺癌预后的相关性。结果在280例乳腺癌患者中,E-钙黏附蛋白表达阴性患者较E-钙黏附蛋白表达阳性患者预后差(生存率对比Log Rank=19.99,P=0.00;无瘤生存率对比Log Rank=21.42,P=0.00)。在32例三阴性乳腺癌患者中,E-钙黏附蛋白表达阴性患者较E-钙黏附蛋白表达阳性患者预后差(生存率对比Log Rank=4.67,P=0.03;无瘤生存率对比:Log Rank=6.54,P=0.01)。结论 E-钙黏附蛋白是乳腺癌及三阴性乳腺癌的预后因子,有助于进一步划分三阴性乳腺癌的亚型。
Objective To investigate the clinical significance of E-cadherin expression for the prognosis of breast cancer and triple-negative breast cancer （TNBC）. Methods We randomly enrolled 280 cases of invasive breast cancer in our hospital from 2003 to 2005 （ the patients with invasive lobular carcinomas were exempted）. E-cadherin expression was determined by immunohistochemistry. Log Rank survival curve was used to analyze the correlation between E-cadherin expression and the prognosis of breast cancer and TNBC. Results In all the 280 cases, the prognosis of E-cadherin-negative patients was significantly worse than that of E-cadherin-positive patients （ overall survival ： Log Rank = 19. 99, P = 0. O0 ; disease-free survival ： Log Rank = 21.42, P=0. 00）. In the 32 TNBC cases, the prognosis of E-cadherin-negative patients was significantly worse than that of E-cadherin-positive patients （ overall survival ： Log Rank = 4. 67, P --- 0. 03 ; disease-free survival ： Log Rank = 6. 54, P = 0. 01 ）. Conclusion E-cadherin is a prognostic factor for breast cancer and TNBC, which might be useful to further classify the subgroups of TNBC.
出处
《中华乳腺病杂志（电子版）》
CAS
2013年第1期39-41,共3页
Chinese Journal of Breast Disease(Electronic Edition)
