摘要
目的探讨精子DNA损伤与精子形态和顶体完整率的关系。方法对280例男性不育者进行精子DNA碎片指数(DFI)分析,并分析精子形态、顶体完整率。结果严重畸形精子症组和顶体完整率异常组,精子DFI值显著增加;精子DFI≥40%组,精子正常形态率、顶体完整率均显著降低;精子DFI与正常形态率、顶体完整率呈显著负相关。结论精子DNA损伤与精子形态、顶体完整率有密切关系,临床应结合精子DNA损伤程度和其他参数评价男性生育能力。
Objective To analyze the relationship between sperm DNA damage and sperm morphology, acrosome integrity. Methods 280 cases of male infertility were examined by sperm DFI,sperm morphology and rate of sperm acrosome integrity. Results The sperm DFI obviously increase with abnormality of sperm morphology and acrosome integrity. In the group which DFI≥40 %, the rate of normal morphology and acrosome integrity decreased significantly, the sperm DFI has obviously negative correlation with normal sperm normal morphology and acosome integrity. Conclusion Sperm DNA damage has correlation with sperm morphology and acrosome integrity. Sperm DNA damage should be concerned in clinical diagnose.
出处
《国际检验医学杂志》
CAS
2013年第6期649-650,共2页
International Journal of Laboratory Medicine
