摘要
为探讨肾小管功能检测在评价原发性肾小球疾病 (PGD)进展中的意义 ,采用ELISA法、生化方法及肾间质病理计量分析法对 4 8例原发性肾小球疾病患儿分别检测肾小管功能 (尿RBP、尿 β2 -MG、尿微量A1b、尿NAG酶 )和肾间质病理改变。结果发现 :⑴肾脏病理损害程度与肾间质损害有关 ;⑵所有病例均有不同程度的肾间质损害及肾小管功能的异常 ;⑶肾小管功能改变与肾间质损害程度有正相关关系 ;显示肾小管功能检测对评价原发性肾小球疾病进展及肾间质损害程度具有重要的临床意义。
To study clinical significance of assay of tubular function in evaluation of the development of PGD,we detected the glomerular tubular function(u-RBP,u-β 2-MG,u-mA1b,u-NAG)and observed the pathologic changes of tubulointerstitium by using the methods of ELISA,biochemistry and scoring of the pathologic damage of tubulointerstitium in all of the 48 cases.Results were as follows:⑴Damages of glomeruli were related to damages of tubulointerstitium in all cases.⑵There were various injury of tubulointerstitium and the disfiguration of renal tubules in all cases.⑶Damages of tubulointerstitium and changes of the function of renal tubules were correlated.These findings suggest that detecting functions of renal tubules have important significances in estimating the development of PGD and the degree of damages in tubulointerstitium.
出处
《中国医师杂志》
CAS
2000年第8期456-458,共3页
Journal of Chinese Physician
关键词
肾小球疾病
病理变化
肾功能试验
Tubulointerstitium
PGD
Pathologic change
Renal function tests
