摘要
目的评价血吸虫病传播阻断地区中老年人空腹血糖水平．分析其与血吸虫病等因素之间的关系。方法选择高邮市毛港村有血吸虫病史且已治愈15年以上者100人，性别、年龄相近的无血吸虫病史300人，检测空腹的血糖水平，同时调查糖尿病史、胆囊病史以及HBsAg阳性等伴随疾病，分析有、无血吸虫病史人群在不同性别、年龄、职业、文化程度，以及伴随胆囊病、HBsAg阳性等之间的血糖水平。结果该村人群平均血糖水平为（5．57±1.59）mmol／L，95％CI为（5.41-5．72）mmol]L，空腹血糖受损（impaired fasting glucose，IFG）、空腹高血糖（diabetes mellitus，DM）的发生率均为6．75％。有血吸虫病史人群血糖水平为（5．60±1．78）mmol／L，95％CI为（5．29-6．01）mmol／L；无血吸虫病史人群血糖水平为（5.56±1．52）mmol／L，95％CI为（5．37～5．74）mmol／L；二者在不同性别、年龄、职业、文化程度，以及伴随胆囊病、HBsAg阳性等之间的血糖水平差异无统计学意义，除工人间的DM差异有统计学意义（χ^2=5．50，P〈0．05）外，其余各组间的IFG、DM发生率差异无统计学意义。除职业组农民外．其他组别间有血吸虫病史人群DM的发生率均大于无病史人群，其中男性组、40-59岁组、工人组、初中以上文化程度组有血吸虫病史者人群DM的发生率约为无病史者的8、2、12、8倍。在多数组别中有血吸虫病史人群血糖95％CI一般高于无病史人群．唯有血吸虫病史组中95％CI上限达到IFG的水平。其中女性性别组、60-69岁年龄组、工人职业组、文盲和初中以上文化程度组的95％CI上限分别为6．43、6．80、6．50、6．35、6．80mmol／L，其余各组95％CI上限在正常值以内。结论血吸虫病患者及时治愈后，其血糖水平与正常人群无明显差别，但部分中老年患者糖耐量受损的风险可能会增加。
Objective To investigate the fasting plasma glucose level in the middle aged and aged people in schistosomiasis transmission interrupted areas and analyze its relevance to schistosomiasis. Methods One hundred cured schistosomiasis patients and 300 residents at same age without shistosomiasis history in Maogang village, Gaoyou City were investigated. The fasting plasma glucose level was detected while the accompanied diseases such as diabetes, gallbladder infection and HBsAg etc. were investigated. The difference of the fasting plasma glucose level between with or without schistosomiasis history, with or without accompanied diseases and different gender, age, occupation and educational level was then analyzed. Results The average fasting plasma glucose of the population in the village was （5.57 ±1.59） mmol/L,95%CI was （5.4-5.72） mmol/L. The incidence of impaired fasting glucose （IFG） as well as diabetes mellitus （DM） was 6.75%. The average fasting plasma glucose of the cured schistosomiasis patients was （5.60 ±1.78） mmol/L,95%CI was （5.29-6.01） mmol/L, while that of the residents without shistosomiasis history was （5.56 ±1.52） mmol/L,95%CI was （5.37-5.74） mmol/L, the difference between two groups was not statistically significant no matter what gender, age, occupation, educational level and accompanied diseases. There was no significant difference for IFG and DM among various groups except the incidence of DM between worker groups （χ^2=5.50,P〈0.05）. The incidence of DM in cured schistosomiasis patients was higher than that in residents without schistosomiasis history for all groups ex-cept farmers, among them it was 8, 2, 12, and 8 fold higher in male, aged 40-59, workers and educational level above junior high school groups of cured schistosomiasis patients, compared with that in corresponding groups of residents without schistosomiasis history. The 95%CI of fasting plasma glucose was higher in cured schistosomi- asis patients than that in residents without schistosomiasis history in most of the groups, among them the upper limits of 95%CI of fasting plasma glucose were 6.43, 6.80, 6.50, 6.35 and 6.80 mmol/L that reached the level of IFG in the groups of female, aged 60-69, worker, illiteracy and above junior high school of cured schistosomiasis patients respectively, while the upper limits of 95%CI were within normal range in the remaining groups. Conclusion There is no significant difference for fasting plasma glucose level between cured schistosomiasis patients and normal population, however the risk of impared glucose tolerance may increase in part of the middle-aged and aged person.
出处
《国际医学寄生虫病杂志》
CAS
2013年第2期83-88,共6页
International JOurnal of Medical Parasitic Diseases
基金
基金项目：江苏省卫生厅血寄地防应用性课题（X201114）
关键词
血吸虫病
空腹血糖
传播阻断
Schistosomiasis
Fasting plasma glucose
Transmission interrupted
