摘要
目的通过对统一性高血压(RH)患者行多导睡眠图(PSG)监测和临床观察,了解RH合并阻塞性睡眠呼吸暂停综合征(OSAS)临床特点。方法对172例RH进行PSG监测,根据呼吸暂停加低通气指数分成中重度OSAS组、轻度或无OSAS组。观察两组临床情况、动态血压和生化指标等。结果 172例RH患者中中重度OSAS发生率为56.39%,与轻度或无OSAS组患者相比,合并中重度OSAS的患者更年轻化[(47.1±11.8)岁vs.(52.3±12.6)岁,P<0.05]、体重指数(BMI)偏高[(28.1±5.8)kg/m2vs.(25.1±6.2)kg/m2,P<0.05],同时高敏C反应蛋白更高[(2.4±1.98)mmol/Lvs.(1.34±1.23)mmol/L,P<0.05]。结论年轻的RH患者更易合并中重度OSAS,同时肥胖和体内炎症水平偏高也是中重度OSAS的主要危险因素。
Objective To understand the clinical characteristics of refractory hypertension（RH）complicating obstructive sleep apnea syndrome（OSAS）through monitoring of polysomnography（PSG）and clinical observation in RH patients.Methods RH patients（n =172）were given PSG monitoring and then divided into moderate-severe OSAS group,mild OSAS group and non-OSAS group according to apnea hyponea index（AHI）.The clinical changes,ambulatory blood pressure and biochemical indexes were observed in 3 groups.Results Of 172 RH patients,the incidence of moderate-severe OSAS was 56.39%.In moderate-severe OSAS group,the patients were more younger [（47.1 ± 11.8）vs.（52.3 ± 12.6）,P〈0.05],body mass index（BMI）was higher [（28.1 ± 5.8）vs.（25.1 ± 6.2）,P〈0.05] and level of hs-CRP was higher [（2.4 ± 1.98）vs.（1.34 ± 1.23）,P〈0.05] compared with other two groups.Conclusion Younger RH patients are easily complicated by moderate-severe OSAS,and at the same time,obesity and higher inflammatory level are major risk factors.
出处
《中国循证心血管医学杂志》
2013年第1期62-63,共2页
Chinese Journal of Evidence-Based Cardiovascular Medicine
